Team
Centre of Tropical Medicine: Abteilung Klinische Forschung des BNITM und Sektion Klinische Tropenmedizin des UKE unter der Leitung von Prof. Michael Ramharter
Im Mittelpunkt unserer Arbeit stehen klinisch relevante Aspekte von Infektionskrankheiten in den Tropen sowie deren reisemedizinische Bedeutung. Gemeinsam mit unseren afrikanischen Partnern engagieren wir uns in klinischen Forschungsprojekten um Behandlungs- und Präventionsmöglichkeiten nachhaltig zu verbessern.
Die Laborgruppen Groger, Mischlinger, Omansen und Zoleko-Manego stellen sich auf der Hauptseite des BNITM vor. Bitte klicken Sie auf die Namen, Sie werden mit den entsprechenden Seiten verlinkt.
Laufende Projekte
Lassafieber zählt zu den viralen hämorrhagischen Fiebern mit häufig schwerem bis tödlichem Krankheitsverlauf. Die Erkrankung ist in einem großen Teil von Westafrika endemisch. Hauptübertragungsweg ist der Kontakt mit dem natürlichen Wirt des Virus, der Vielzitzenmaus und deren Ausscheidungen, das Virus kann jedoch auch von Mensch zu Mensch übertragen werden. Eine Impfung gegen die Erkrankung sind bisher nicht verfügbar, und die Behandlungsmöglichkeiten beschränken sich auf unterstützende Maßnahmen sowie das Medikament Ribavirin.
Dexamethason ist ein Kortikosteroid, das Gewebsentzündung unterdrücken kann und wird deshalb routinemäßig für eine Vielzahl von Erkrankungen verwendet. Es gibt Hinweise darauf, dass Dexamethason auch bei schwerem Lassafieber vielversprechend sein könnte.
Am Irrua Specialist Teaching Hospital (ISTH) in Nigeria, eines der größten Behandlungszentren für Lassafieber in Westafrika, wurde Dexamethason bereits erfolgreich in der klinischen Praxis eingesetzt, um Doppelinfektionen mit dem Lassa-Virus und SARS-CoV-2 zu behandeln. Die Kombination aus Ribavirin und Dexamethason wurde zuvor für die Behandlung von schwerem Krim-Kongo-hämorrhagischem Fieber getestet.
Die klinische Studie LADEX (Lassafieber-Zusatzbehandlung mit Dexamethason) soll erstmals eine Kombination aus dem Standard-of-care (Ribavirin) und Dexamethason bei Patienten mit moderatem oder schwerem Lassafieber evaluieren.
LADEX ist eine prospektive, offene, randomisierte, kontrollierte Phase-II-Klinikstudie mit zwei Gruppen:
a. Antivirale standard-of-care Therapie mit Ribavirin
b. Antivirale standard-of-care Therapie Ribavirin + Dexamethason
42 Patienten mit moderatem oder schwerem Lassafieber sollen bis 2026 eingeschlossen werden. Der Studienbeginn ist für Ende 2023 geplant. Das BNITM ist der Sponsor der Studie, die Rekrutierung der Studienteilnehmer erfolgt am ISTH.
Das Ziel der Studie ist es, das Outcome von mittel- bis schwer erkrankten Lassafieberpatienten zu verbessern.
Klinische Evaluierung von Antimalaria-Tripletherapie mit Atovaquon-Proguanil zur Behandlung von Malaria in afrikanischen Kindern (ASAAP)
Bei ASAAP handelt es sich um eine klinische Studie zur Bewertung der Wirksamkeit, Sicherheit, Verträglichkeit und Pharmakokinetik eines neuen Malaria-Kombinationspräparats, mit einer Laufzeit von 48 Monaten. Der Schwerpunkt liegt auf dessen erfolgreicher Anwendung in einer der größten und anfälligsten Bevölkerungsgruppen Afrikas - Kinder von 0-5 Jahren. Das übergeordnete Ziel ist die Entwicklung neuer Antimalariabehandlungen durch die Kombination bestehender, wirksamer Arzneimittel zur Behandlung von Malaria bei afrikanischen Kindern durch die Förderung der afrikanischen und europäischen Forschungszusammenarbeit und die Stärkung der Fähigkeit afrikanischer Institutionen zur Durchführung klinischer Forschung.
ASAAP ist Teil des von der Europäischen Union (EU) geförderten European and Developing Countries Clinical Trials Partnership 2 (EDCTP 2) Programms und wird vom Bundesministerium für Bildung und Forschung (BMBF) und dem Nationalen Institut für Gesundheit und medizinische Forschung in Frankreich (INSERM) unterstützt.
Das Projekt wird von Dr. Oumou Maiga-Ascofaré vom BNITM in Hamburg, Deutschland und dem KCCR in Kumasi, Ghana geleitet, unter der Autorität der Kwame Nkrumah University of Science and Technology (KNUST) und in Zusammenarbeit mit:
Weitere Informationen finden Sie auf der EDCTP Homepage unter https://www.edctp.org/ sowie auf der Projekt-Homepage unter https://asaap-malaria.org/
MAMAH
Eine Malaria-Infektion während der Schwangerschaft wirkt sich erheblich auf die Gesundheit von Müttern und Neugeborenen aus, insbesondere bei HIV-infizierten Frauen. In Afrika werden jährlich mindestens eine Million Schwangerschaften mit Malaria und HIV co-infiziert. Die Interaktion zwischen den beiden Infektionen ist in der Schwangerschaft besonders schädlich, was zu einem erhöhten Risiko für Malaria und HIV-Viruslasten führt, was die Häufigkeit der Übertragung von HIV von der Mutter auf ihr Kind (MTCTHIV) erhöhen kann.
Eine intermittierende vorbeugende Behandlung in der Schwangerschaft (IPTp) mit Sulfadoxin-Pyrimethamin (SP) wird zur Vorbeugung von Malaria bei HIV-nicht-infizierten Frauen empfohlen. Bei HIV-infizierten Patienten mit Cotrimoxazol-Prophylaxe (CTXp) ist sie wegen möglicher Nebenwirkungen kontraindiziert. Eine kürzlich durch die EDCTP finanzierte Studie zeigte, dass zwar ein wirksames Antimalariamittel (Mefloquin) zu CTXp und lang anhaltende mit Insektiziden behandelte Netze (LLITNs) bei HIV-infizierten schwangeren Frauen die Malariaprävention und die Gesundheit von Müttern verbessert, jedoch nicht gut vertragen wurde und die HIV-Viruslast bei der Entbindung und das Risiko für MTCT-HIV erhöhte. Dies unterstreicht die Notwendigkeit alternative Arzneimittel mit einem besseren Verträglichkeits- und Sicherheitsprofil zu finden, um Malaria in dieser anfälligen Gruppe zu verhindern und die pharmakologischen Wechselwirkungen zwischen Arzneimitteln gegen Malaria und Antiretroviralen (ARV) weiter zu erforschen.
Dihydroartemisinin-Piperaquin (DHA-PPQ) verbessert nachweislich den Malariaschutz bei Frauen ohne HIV-Infektion und stellt den vielversprechendsten Kandidaten für IPTp bei HIV-infizierten schwangeren Frauen dar. Es gibt jedoch nur begrenzte Informationen zur Pharmakokinetik von DHA-PPQ bei gleichzeitiger Anwendung von ARV-Medikamenten und CTX.
Zielsetzung:
Eine randomisierte, placebokontrollierte Doppelblindstudie zur Bewertung der Sicherheit und Wirksamkeit von DHA-PPQ für IPTp bei HIV-infizierten schwangeren Frauen, die CTXp- und ARV-Medikamente erhalten und LLITNs verwenden, wird in Gabun und Mosambik durchgeführt, wo Malaria- und HIV-Infektionen moderat bis stark verbreitet sind. Die Möglichkeit einer pharmakokinetischen Interaktion zwischen DHA-PPQ- und ARV-Medikamenten wird untersucht. Frauen erhalten eine ARV-Therapie gemäß den nationalen Richtlinien, und ihre Kinder werden bis zu einem Jahr beobachtet, um die Auswirkungen von DHA-PPQ auf MTCT-HIV zu bewerten.
Das fünf Jahre dauernde Projekt wird von der EDCTP finanziert und von ISGlobal (Barcelona, Spanien) in Zusammenarbeit mit dem Centre de Recherches Médicales de Lambaréné (CERMEL, Gabun), dem Gesundheitsforschungszentrum Manhiça/Fundaçao Manhiça (CISM/FM, Mozambique), der Medizinischen Universität Wien (MedUni Wien, Österreich), dem Bernhard-Nocht-Institut für Tropenmedizin (BNITM, Deutschland) und der Eberhard-Karls-Universität Tübingen (EKUT, Deutschland) koordiniert. Diese Studie wird schlüssige Beweise liefern, um die Belastung der beiden wichtigsten poverty-related diseases (PRDs) bei HIV-infizierten schwangeren Frauen zu reduzieren, die von Malaria bedroht sind.
Gesamtförderung: 2.985.000 €
„Dieses Projekt ist Teil des EDCTP2-Programms, das von der Europäischen Union unterstützt wird.“
Abgeschlossene Projekte
Etablierung klinischer Studienorte und Durchführung von Medikamentenstudien zur Verbesserung der Behandlung von Lassa-Fieber in endemischen Regionen
Die meisten afrikanischen Länder sind nicht in der Lage, Erreger mit epidemischem Potential sicher zu diagnostizieren und auf Ausbrüche adäquat zu reagieren. Das weitgehende Fehlen dieser Kapazitäten hat zur verzögerten Antwort auf den Ebola-Virus Ausbruch in West-Afrika beigetragen. Dazu kommt das Fehlen von medizinischen Gegenmaßnahmen für Erkrankungen mit epidemischem Potential, die ihren Ursprung in Afrika haben. Zu diesen Erkrankungen zählt ebenfalls Lassa-Fieber, das ähnlich wie die Ebola-Viruserkrankung ein sogenanntes virales hämorrhagisches Fieber ist. Es ist in weiten Teilen West-Afrikas endemisch. Jährlich werden mehrere hunderttausend Infektionen geschätzt, die Sterblichkeit im Krankenhaus liegt bei 30%. Eine Impfung oder sichere Behandlung gibt es nicht. Aus diesen Gründen wurde Lassa-Fieber von der WHO auf die Liste der Erkrankungen mit dringendem Forschungs- und Entwicklungsbedarf gesetzt.
Im Rahmen dieses Projekts werden in Nigeria Kapazitäten zur schnellen Eindämmung von Lassa-Fieber Ausbrüchen aufgebaut und medizinische Gegenmaßnahmen bei Lassa-Fieber Erkrankungen entwickelt. Dazu ist es erforderlich, bestehende therapeutische Optionen (Ribavirin) zu überprüfen, da Zweifel an der Wirksamkeit des Medikaments bestehen, und gleichzeitig neue Medikamente (z.B. Favipiravir) am Menschen zu prüfen. Dazu müssen entsprechende Kapazitäten für klinische Studien vor Ort aufgebaut werden und erste Studien mit den beiden Medikamenten initiiert werden.
Gemeinsam mit dem Irrua Specialist Teaching Hospital (ISTH) in Edo State werden Kapazitäten in Nigeria aufgebaut und Medikamentenstudien zum Aufbau der lokalen Expertise initiiert:
Das Projekt SAFARI wird in Zusammenarbeit mit dem FMCO in Ondo State, Nigeria, dem Institut National de la Santé et de la Recherche Médicale (Inserm), der Université Bordeaux und der Alliance for International Medical Action (ALIMA) durchgeführt.
Weitere Informationen zu diesem Projekt finden Sie auf der GHPP (Global Health Protection Programme) Homepage unter https://ghpp.de/de/projekte/lassa-nigeria/.
TROPICSAFE - Medizinischer Transport von Patienten mit tropischen Erkrankungen unter sicheren Umständen
Der Patiententransport ist eine gefährliche Aufgabe, wenn Fachkräfte mit ansteckenden Krankheiten zu kämpfen haben. Heutzutage gibt es mehrere Protokolle zur Behandlung von Tropenkrankheiten, die Angehörigen der Gesundheitsberufe fordern jedoch spezifische Richtlinien und praktischeres Schulungsmaterial mit standardisierten Kriterien. Darüber hinaus macht der Schengen-Raum mit der Aufhebung der Binnengrenzen in der EU gemeinsame Strategien und Verfahren erforderlich, um einem möglichen Ausbruch von Viren durch transnationale Maßnahmen entgegenzuwirken.
Das TROPICSAFE-Projekt zielt darauf ab, ein standardisiertes Trainingsprotokoll auf europäischer Ebene zu entwickeln, das sich auf die Beförderung von Patienten mit Tropenkrankheiten konzentriert.
Diese Schulung wird auf einer Open Online Learning Platform veröffentlicht. Die Schulung umfasst audiovisuelle Unterstützung, z. B. Videos, Bilder und Grafiken, um die Sicherheitsverfahren, die vom Fachpersonal befolgt werden sollten, besser zu veranschaulichen. Sie wird mit Fragen- und Antworttests zur Bewertung des Schulungsprozesses abgeschlossen und in die Sprachen der Arbeitsgemeinschaft übersetzt.
Die Arbeitsgemeinschaft setzt sich aus fünf Institutionen zusammen, die den Sektor in ihrem Land genau kennen und die Interessen von Arbeitnehmern, Angehörigen der Gesundheitsberufe und Ausbildern vertreten. Unter der Leitung des BNITM sind folgende weitere Einrichtungen an diesem Projekt beteiligt:
Das Projekt wird vom ERASMUS+ Programm der EU über 24 Monate mitfinanziert.
FAIR - Fighting Antibiotic Resistances
DVT-Study - Deep Vein Thrombosis Study
HHECO - Der Einfluss von Helicobacter pylori-Koinfektionen auf die Immunregulation und den klinischen Verlauf von HIV-Patienten in Ghana
In letzter Zeit hat das Zusammenspiel zwischen dem Humanen Immundefizienzvirus (HIV) und der Infektion mit Helicobacter pylori die Aufmerksamkeit auf sich gezogen. Eine Reihe von Studien berichtete über günstigere Immun- und klinische Parameter bei HIV-infizierten Personen mit H. pylori. Die inverse Beziehung zwischen der H. pylori-Infektion und der Immunkompetenz des Wirts ist unerwartet, da die meisten chronischen Infektionen bei Patienten mit fortschreitender HIV-Erkrankung häufiger auftreten.
Unser Ziel ist es, die Auswirkungen von H. pylori und anderen relevanten Koinfektionen auf die Immunaktivierung und die klinischen Ergebnisse in einer Kohorte von 1000 HIV-positiven Patienten im Komfo Anokye Teaching Hospital in Kumasi, Ghana, zu untersuchen.
KCS - Kumasi-Kohortenstudie zur Wirksamkeit von ART der ersten und zweiten Linie bei HIV-Patienten in Ghana
Im Jahr 2011 wurden in Ghana 56.000 erwachsene HIV-infizierte Personen (PLHIV) mit antiretroviralen Medikamenten behandelt. Dies entspricht einem Viertel aller Erwachsenen mit HIV in Ghana und einer Abdeckung von 47% bei Menschen mit fortgeschrittener HIV-Infektion.
In einer Kohorte von 1500 HIV-infizierten Patienten mit First-Line-ART im Komfo Anokye Teaching Hospital in Kumasi sollte der Anteil der Behandlungsversager und ihrer Determinaten untersucht werden. Während dieser Studie haben wir eine Kohorte von PLHIV etabliert, die nach virologischem oder immunologischem Therapieversagen auf Second-Line-ART umgestellt wurde. Auch hier wollen wir die Wirksamkeit dieser Second-Line-ART untersuchen, die aufgrund der Tatsache, dass es in Ghana keine Third-Line-Option gibt, von großem Interesse ist.
Auszeichnungen
Memento Forschungspreis 2024, Michael Ramharter (November 2024)
DTG Preis für die beste Präsentation 2024, Marabelle Essandoh (September 2024)
Medizinische Fakultät Hamburg: Preis als "Student of the Year", Dorothea Ekoka Mbassi (Juni 2024)
Nordeuropäische Konferenz für Reisemedizin (NECTM9) Preis für die beste Präsentation, Marabelle Essandoh (Mai 2024)
DTG Preis für Tropenmedizin 2023, Dr. Johannes Mischlinger (Juni 2023)
DTG Posterpreis 2023, Charlotte Kriebel (Juni 2023)
Wolfgang-Stille-Wissenschaftspreis 2022, Paul-Ehrlich-Gesellschaft für Infektionstherapie e.V., Dr. Mirjam Groger (April 2023)
BNITM Research Highlight, Q2 2022, Dr. Mirjam Groger (Juli 2022)
VdF Promotionspreis für Medizin 2022, Dr. Luzia Veletzky (Juni 2022)
DTG Posterpreis, Hannah Müller (Juni 2022)
DTG Preis für Tropenmedizin 2021, Dr. Benno Kreuels (Juni 2021)
Dr. Martini-Preis 2021, Dr. Luzia Veletzky (Februar 2021)
BNITM Research Highlight, Q2 2020, Dr. Luzia Veletzky (Juni 2020)
VdF Promotionspreis für Medizin 2020, Dr. Johannes Mischlinger (September 2020)
DZIF-Doktorandenpreis der DGI 2019, Dr. Till Omansen (November 2019)
Stephan-Weiland-Preis 2019, Dr. Johannes Mischlinger (September 2019)
VdF Promotionspreis für Medizin 2019, Dr. Mirjam Groger (Juni 2019)
ISTM-Forschungspreis 2019, PD Dr. Silja Bühler (April 2019)
DTG Posterpreis, Dr. Mirjam Groger (April 2019)
ÖGTPM Travel Grant, Dr. Mirjam Groger (März 2019)
Dr.-Martini-Preis 2019, Dr. Johannes Mischlinger (Februar 2019)
ASTMH Young Investigator Award “Honorable mentionee”, Dr. Johannes Mischlinger (Oktober 2018)
ASTMH Young Investigator Award “Honorable mentionee”, Dr. Luzia Veletzky (Oktober 2018)
CERMEL Research Award 2018, Prof. Michael Ramharter (2018)
Poster-Preis auf dem Kongress für Infektionskrankheiten und Tropenmedizin, Dr. Christof Vinnemeier (Juni 2018)
Graduierungen
Dr. med. univ. Luzia Veletzky, PhD (2021)
Dr. med. Till Omansen, PhD (2020)
Dr. med. univ. Johannes Mischlinger, PhD (2019)
Dr. med. univ, Mirjam Groger, PhD (2018)
Das Bernhard-Nocht-Zentrum für Klinische Studien (BNCCT) ist Teil der Sektion Tropenmedizin der I. Medizinischen Klinik des Universitätsklinikum Hamburg-Eppendorf (UKE). Es befindet sich im historischen Gebäude des Bernhard-Nocht-Instituts für Tropenmedizin (BNITM).
Seit 2008 führen wir Impfstudien durch und bieten umfassende Dienstleistungen rund um die Durchführung von klinischen Studien in den Bereichen Reisemedizin und Tropenmedizin.
Zu diesen Leistungen gehören die Leitung von multizentrischen Studien, GCP-konforme randomisierte klinische Studien, Erstellung von studienbezogenen Dokumenten, Beratungsleistungen einschließlich Studien- und Protokolldesign, sowie Daten- und Sicherheitsüberwachung.
Weitere Informationen zum Bernhard Nocht Centre for Clinical Trials (BNCCT) finden Sie hier:
Pharmacokinetics of ribavirin in the treatment of Lassa fever: An observational clinical study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.
Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C.
Clin Infect Dis. 2022 Jul 26:ciac578. doi: 10.1093/cid/ciac578.
Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial
Mirjam Groger, Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Nsengi Y Ntamabyaliro, Gauthier Kahunu Mesia, Trésor Bodjick Muena Mujobu, Lia Betty Dimessa Mbadinga, Rella Zoleko Manego, Diane Egger-Adam, Isabelle Borghini-Fuhrer, Jangsik Shin, Robert Miller, Sarah Arbe-Barnes, Stephan Duparc, Michael Ramharter
Lancet Microbe . 2022 May 30;S2666-5247(22)00092-1. doi: 10.1016/S2666-5247(22)00092-1. Online ahead of print.
Drug-induced hypersensitivity to artemisinin-based therapies for malaria.
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol. 2022 Feb;38(2):136-146. doi: 10.1016/j.pt.2021.08.011. Epub 2021 Sep 21.
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months.
Thomas SJ, Moreira ED Jr, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Polack FP, Zerbini C, Bailey R, Swanson KA, Xu X, Roychoudhury S, Koury K, Bouguermouh S, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Yang Q, Liberator P, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Gruber WC, Jansen KU; C4591001 Clinical Trial Group.
N Engl J Med. 2021 Nov 4;385(19):1761-1773.
Predictive Performance of Rapid Diagnostic Tests for Falciparum Malaria and Its Modeled Impact on Integrated Community Case Management of Malaria in Sub-Saharan African Febrile Children.
Mischlinger J, Dudek V, Ramharter M.
Clin Infect Dis. 2021 Sep 7;73(5):e1158-e1167. doi: 10.1093/cid/ciaa1942.
Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.
Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M; CANTAM study group.
PLoS Med. 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669. eCollection 2021 Jun.
Hookworm infection in returning travellers and migrants: a 10-year case series at a German center for tropical medicine.
Saffar F, Kurth F, Tannich E, Ramharter M, Jochum J.
J Travel Med. 2021 Jan 6;28(1):taaa183. doi: 10.1093/jtm/taaa183.
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, Bailey R, Swanson KA, Roychoudhury S, Koury K, Li P, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Jansen KU, Gruber WC; C4591001 Clinical Trial Group.
N Engl J Med. 2020 Dec 31;383(27):2603-2615.
Paediatric formulations of artemisinin-based combination therapies for treating uncomplicated malaria in children
Bélard S, Ramharter M, Kurth F.
Cochrane Database Syst Rev . 2020 Dec 8;12(12):CD009568. doi: 10.1002/14651858.CD009568.pub2.
Burden of disease in Gabon caused by loiasis: a cross-sectional survey
Veletzky L, Hergeth J, Stelzl D, Mischlinger J, Manego Zoleko R, Mombo-Ngoma G, McCall M, Adegnika A, Agnandji S, Metzger W, Matsiegui P, Lagler H, Mordmüller B. Budke C, Ramharter M.
The Lancet Infectious Diseases. 2020 June 22; https://doi.org/10.1016/S1473-3099(20)30256-5
Imported Malaria in Countries where Malaria Is Not Endemic: a Comparison of Semi-immune and Nonimmune Travelers
Mischlinger J, Rönnberg C, Álvarez-Martínez MJ, Bühler S, Paul M, Schlagenhauf P, Petersen E, Ramharter M.
Clin Microbiol Rev. 2020 Mar 11;33(2):e00104-19. doi: 10.1128/CMR.00104-19. Print 2020 Mar 18. PMID: 32161068 Free PMC article. Review.
Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis.
Eberhardt KA, Mischlinger J, Jordan S, Groger M, Günther S, Ramharter M.
Int J Infect Dis. 2019 Oct;87:15-20. doi: 10.1016/j.ijid.2019.07.015. Epub 2019 Jul 26.
Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting.
Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Manego Zoleko R, Kim J, Klicpera A, Meyer EL, Blessborn D, Winterberg M, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Fuehrer HP, Ramharter M.
Clin Infect Dis. 2019 Apr 19. pii: ciz131. doi: 10.1093/cid/ciz131. [Epub ahead of print]
The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis
Ramharter M, Butler J, Mombo-Ngoma G, Nordmann T, Davi SD, Zoleko Manego R.
Lancet Infect Dis . 2024 Mar;24(3):e165-e178. doi: 10.1016/S1473-3099(23)00438-3. Epub 2023 Oct 16.
Q fever: a rare zoonotic disease as a cause of pneumonia in travellers
Tamara Nordmann, Dorothea Wiemer, Matthias Halfter, Andrea Vanegas Ramirez, Dennis Tappe, Sabine Jordan, Michael Ramharter, Johannes Jochum
Journal of Travel Medicine, Volume 31, Issue 3, April 2024, taae001, https://doi.org/10.1093/jtm/taae001
Safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnant women with HIV from Gabon and Mozambique: a randomised, double-blind, placebo-controlled trial
Raquel Gonzále, Tacilta Nhampossa, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Meral Esen, André-Marie Tchouatieu, Anete Mendes, Antía Figueroa-Romero, Rella Zoleko-Manego, Bertrand Lell, Heimo Lagler, Linda Stoeger, Lia Betty Dimessa, Myriam El Gaaloul, Sergi Sanz, Susana Méndez, Mireia Piqueras, Esperança Sevene, Michael Ramharter, Francisco Saúte, Clara Menendez; MAMAH study group
Lancet Infect Dis . 2024 May;24(5):476-487. doi: 10.1016/S1473-3099(23)00738-7. Epub 2024 Jan 12.
Safety and efficacy of pyronaridine–artesunate paediatric granules in the treatment of uncomplicated malaria in children: insights from randomized clinical trials and a real-world study
Michael Ramharter, Abdoulaye A Djimde, Isabelle Borghini-Fuhrer, Robert Miller, Jangsik Shin, Adam Aspinall, Naomi Richardson, Martina Wibberg, Lawrence Fleckenstein, Sarah Arbe-Barnes, Stephan Duparc
Malar J . 2024 Feb 28;23(1):61. doi: 10.1186/s12936-024-04885-3.
Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections
Luzia Veletzky, Kirsten Alexandra Eberhardt, Jennifer Hergeth, Daniel Robert Stelzl, Rella Zoleko Manego, Ruth Kreuzmair, Gerrit Burger, Johannes Mischlinger, Matthew B B McCall, Ghyslain Mombo-Ngoma, Ayôla Akim Adegnika, Selidji Todagbe Agnandji, Pierre Blaise Matsiegui, Bertrand Lell, Peter Kremsner, Benjamin Mordmüller, Dennis Tappe, Michael Ramharter
PLoS Negl Trop Dis . 2024 Mar 14;18(3):e0012054. doi: 10.1371/journal.pntd.0012054. eCollection 2024 Mar.
Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis
WWARN ACT Malaria and Malnutrition Study Group: Kasia Stepniewska, Richard Allan, Anupkumar R Anvikar, Thomas A Anyorigiya, Elizabeth A Ashley, Quique Bassat, Elisabeth Baudin, Anders Bjorkman, Maryline Bonnet, Caroline Boulton, Teun Bousema, Gwenaelle Carn, Verena I Carrara, Umberto D'Alessandro, Timothy Me Davis, Lise Denoeud-Ndam, Meghna Desai, Abdoulaye A Djimde, Grant Dorsey, Jean-François Etard, Catherine Falade, Caterina Fanello, Oumar Gaye, Raquel Gonzalez, Francesco Grandesso, Anastasia D Grivoyannis, Rebecca F Grais, Georgina S Humphreys, Deus S Ishengoma, Corine Karema, Kassoum Kayentao, Kalynn Kennon, PeterG Kremsner, Moses Laman, Ibrahim M Laminou, Eusebio Macete, Andreas Martensson, Mayfong Mayxay, Hervé Ib Menan, Clara Menéndez, Brioni R Moore, Carolyn Nabasumba, Jean-Louis Ndiaye, Abel Nhama, Francois Nosten, Marie Onyamboko, Aung Pyae Phyo, Michael Ramharter, Philip J Rosenthal, Birgit Schramm, Yagya D Sharma, Sodiomon B Sirima, Nathalie Strub-Wourgaft, Khadime Sylla, Ambrose O Talisuna, Emmanuel A Temu, Julie I Thwing, Halidou Tinto, Giovanni Valentini, Nicholas J White, Adoke Yeka, Sheila Isanaka, Karen I Barnes, Philippe J Guerin
Lancet Glob Health . 2024 Apr;12(4):e631-e640. doi: 10.1016/S2214-109X(24)00003-2.
Assessing the Incidence of Snakebites in Rural Gabon—A Community-Based, Cross-Sectional Pilot Survey
Saskia Dede Davi, Anita Lumeka, Teite Rebecca Hildebrandt, Lilian Rene Endamne, Cedric Otchague, Dearie Glory Okwu, Rica Artus, Friederike Hunstig, Rella Zoleko Manego, Jörg Blessmann, Peter G. Kremsner, Bertrand Lell, Ghyslain Mombo-Ngoma, Selidji Todagbe Agnandji, Michael Ramharter, Benno Kreuels
Trop. Med. Infect. Dis. 2024, 9(4), 68; https://doi.org/10.3390/tropicalmed9040068
Lack of Suspicion of Dapsone Hypersensitivity Syndrome in a Leprosy Patient: Case Report with Fatal Outcome
Ruth Ansah, Ebenezer Ameyaw Arkoh, Benedict Okoe Quao, Mirjam Groger
Res Rep Trop Med . 2023 Dec 29:14:135-139. doi: 10.2147/RRTM.S434947. eCollection 2023.
Dynamics of Plasmodium species and genotype diversity in adults with asymptomatic infection in Gabon
Juliana Inoue, Annika Galys, Miriam Rodi, Dorothea Ekoka Mbassi, Ghyslain Mombo-Ngoma, Ayôla A Adegnika, Michael Ramharter, Rella Zoleko-Manego, Peter G Kremsner, Benjamin Mordmüller, Jana Held
Int J Infect Dis . 2024 Jun:143:107013. doi: 10.1016/j.ijid.2024.107013. Epub 2024 Mar 16. Dynamics of Plasmodium species and genotype
A randomized assessors-blind clinical trial to evaluate the safety and the efficacy of albendazole alone and in combination with mebendazole or pyrantel for the treatment of Trichuris trichiura infection in school-aged children in Lambaréné and surroundings
Paul Alvyn Nguema Moure, Moustapha Nzamba Maloum, Gédéon Prince Manouana, Roméo-Aimé Laclong Lontchi, Mirabeau Mbong Ngwese, Jean Ronald Edoa, Jeannot Fréjus Zinsou, Brice Meulah, Saidou Mahmoudou, Elsy Mirna N'noh Dansou, Yabo Josiane Honkpehedji, Bayode Romeo Adegbite, Selidji Todagbe Agnandji, Michael Ramharter, Bertrand Lell, Steffen Borrmann, Peter G Kremsner, Jean Claude Dejon-Agobé, Ayôla Akim Adegnika
Antimicrob Agents Chemother . 2024 May 2;68(5):e0121123. doi: 10.1128/aac.01211-23. Epub 2024 Apr 2.
Rapid diagnostic tests for Lassa fever: what do we aim for?
Mirjam Groger, Michael Ramharter
Lancet Infect Dis . 2024 May 8:S1473-3099(24)00235-4. doi: 10.1016/S1473-3099(24)00235-4. Online ahead of print.
Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study
Valentin Joste, Romain Coppée, Justine Bailly, Yann Rakotoarivony, Francine Ghislaine Toko Tchokoteu, Shany Achache, Bruno Pradines, Gilles Cottrell, Frédéric Ariey, Nimol Khim, Jean Popovici, Toshihiro Mita, Mirjam Groger, Michael Ramharter, Timothy Egbo, Dennis W Juma, Hoseah Akala, Sandrine Houzé, Jérôme Clain; Investigation Study Group
Lancet Microbe . 2024 Jul;5(7):669-678. doi: 10.1016/S2666-5247(24)00054-5. Epub 2024 May 15.
Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting
Gerrit Burger, Rafiou Adamou, Ruth Kreuzmair, Wilfrid Ndzebe Ndoumba, Dorothea Ekoka Mbassi, Anne Marie Nkoma Mouima, Carole Mamgno Tabopda, Roukoyath Moyoriola Adegnika, Ayong More, Dearie Glory Okwu, Lia-Betty Dimessa Mbadinga, Carlos Lamsfus Calle, Luzia Veletzky, Wolfram Gottfried Metzger, Benjamin Mordmüller, Michael Ramharter, Ghyslain Mombo-Ngoma, Ayola Akim Adegnika, Rella Zoleko-Manego, Matthew B B McCall
PLoS Negl Trop Dis . 2024 May 21;18(5):e0012203. doi: 10.1371/journal.pntd.0012203. eCollection 2024 May.
Perceptions of yellow fever emergency mass vaccinations among vulnerable groups in Uganda: A qualitative study
Lena Huebl, Aloysious Nnyombi, Aban Kihumuro, Denis Lukwago, Eddy Walakira, Ruth Kutalek
PLoS Negl Trop Dis . 2024 May 13;18(5):e0012173. doi: 10.1371/journal.pntd.0012173. eCollection 2024 May.
Evaluation of knowledge, attitude and practice towards loiasis in the rural community of Sindara, in central African Gabon
Teite Rebecca Hildebrandt, Saskia Dede Davi, Anita Lumeka Kabwende, Lilian Rene Endamne, Esther Mehmel, Maximilian Rakotonirinalalao, Ayodele Alabi, Rella Zoleko Manego, Peter G Kremsner, Bertrand Lell, Ayôla Akim Adegnika, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Selidji Todagbe Agnandji, Michael Ramharter
PLoS Negl Trop Dis . 2024 May 23;18(5):e0012109. doi: 10.1371/journal.pntd.0012109. eCollection 2024 May.
Safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnant women with HIV from Gabon and Mozambique: a randomised, double-blind, placebo-controlled trial
Raquel González, Tacilta Nhampossa, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Meral Esen, André-Marie Tchouatieu, Anete Mendes, Antía Figueroa-Romero, Rella Zoleko-Manego, Bertrand Lell, Heimo Lagler, Linda Stoeger, Lia Betty Dimessa, Myriam El Gaaloul, Sergi Sanz, Susana Méndez, Mireia Piqueras, Esperança Sevene, Michael Ramharter, Francisco Saúte, Clara Menendez; MAMAH study group
Lancet Infect Dis . 2024 May;24(5):476-487. doi: 10.1016/S1473-3099(23)00738-7. Epub 2024 Jan 12.
Sleep apnea in patients undergoing coronary artery bypass grafting: Impact on perioperative outcomes
Kassar Farha, Mustafa Gercek, Muhammed Gercek, Johannes Mischlinger, Volker Rudolph, Jan F. Gummert, Charbel Saad, Anas Aboud, Henrik Fox
J Sleep Res. 2024 Feb 26:e14181. doi: 10.1111/jsr.14181. Epub ahead of print. PMID: 38410033.
Human Placental Schistosomiasis—A Systematic Review of the Literature
Jacob Gerstenberg, Sasmita Mishra, Martha Holtfreter, Joachim Richter, Saskia Dede Davi, Dearie Glory Okwu, Michael Ramharter, Johannes Mischlinger, Benjamin T Schleenvoigt; TropNet
Pathogens . 2024 Jun 3;13(6):470. doi: 10.3390/pathogens13060470.
Significant increase in malaria deaths in Germany after the end of the COVID-19 pandemic
Fine Klitzsch, Florian Kurth, Michael Ramharter
Dtsch Med Wochenschr . 2024 Jul;149(13):792-794. doi: 10.1055/a-2312-5950. Epub 2024 Jun 11.
Establishment of a national travel medicine vaccination network to assess reactogenicity of new and rarely used vaccines: a TropNet study.
Clara Köpke, Camilla Rothe, Andreas Zeder, Gerhard Boecken, Torsten Feldt, Christian Janke, Sabine Jordan, Micha Löbermann, Andreas Müller, Hans-Martin Orth, Luise Marie Prüfer-Krämer, Johannes Schäfer, Günther Slesak, August Stich, Sabine Bélard, Nico Thul, Sören L Becker, Sophie Schneitler; TravVacNet-Group
J Travel Med . 2024 Jul 6:taae092. doi: 10.1093/jtm/taae092.
Real-life effectiveness of anti-malarial treatment regimens: what are we aiming for?
Dorothea Ekoka Mbassi, Christoph Pfaffendorf, Ghyslain Mombo-Ngoma, Benno Kreuels, Michael Ramharter
Malar J. 2023 Jun 20;22(1):189. doi: 10.1186/s12936-023-04606-2. PMID: 37340324; PMCID: PMC10280843.
Rabies post-exposure prophylaxis of international travellers - Results from two major German travel clinics
Saffar F, Heinemann M, Heitkamp C, Stelzl DR, Ramharter M, Schunk M, Rothe C, Bühler S.
Travel Med Infect Dis. 2023 May-Jun;53:102573. doi: 10.1016/j.tmaid.2023.102573. Epub 2023 Apr 20. PMID: 37087082.
Efficacy, safety, and tolerability of albendazole and ivermectin based regimens for the treatment of microfilaraemic loiasis in adult patients in Gabon: A randomized controlled assessor blinded clinical trial.
Zoleko-Manego R, Kreuzmair R, Veletzky L, Ndzebe-Ndoumba W, Ekoka Mbassi D, Okwu DG, Dimessa-Mbadinga-Weyat LB, Houtsa-Temgoua RD, Mischlinger J, McCall MBB, Kresmner PG, Agnandji ST, Lell B, Adegnika AA, Mombo-Ngoma G, Ramharter M.
PLoS Negl Trop Dis. 2023 Aug 28;17(8):e0011584. doi: 10.1371/journal.pntd.0011584. PMID: 37639396; PMCID: PMC10491396.
Symptoms of illness during travel and risk factors for non-adherence to malaria prophylaxis-a cross-sectional study in travellers from Germany.
Reinsberg F, Moehlmann MW, Krumkamp R, Landsmann L, Heitkamp C, Jochum J, Addo M, Ramharter M, Radt C, Rothe C, Vinnemeier C, Kreuels B.
J Travel Med. 2023 May 18;30(3):taad055. doi: 10.1093/jtm/taad055. PMID: 37098163; PMCID: PMC10198432.
Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project).
Figueroa-Romero A, Mendes A, Mombo-Ngoma G, Mischlinger J, Esen M, Vogler M, Mazuze M, Mombo-Nzamba L, Mbadinga B, Sanz S, Ramharter M, Saute F, Nhampossa T, Menendez C, González R.
BMJ Open. 2023 May 22;13(5):e067083. doi: 10.1136/bmjopen-2022-067083. PMID: 37217271; PMCID: PMC10230341.
Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria
Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C.
Clin Infect Dis. 2023 Feb 8;76(3):e841-e848. doi: 10.1093/cid/ciac578. PMID: 35881530; PMCID: PMC9907520.
Alveolar echinococcosis in immunocompromised hosts.
Autier B, Gottstein B, Millon L, Ramharter M, Gruener B, Bresson-Hadni S, Dion S, Robert-Gangneux F.
Clin Microbiol Infect. 2023 May;29(5):593-599. doi: 10.1016/j.cmi.2022.12.010. Epub 2022 Dec 15. PMID: 36528295.
Focussed Assessment with Sonography in acute Lassa Fever (FASLa): Development of a point-of-care protocol and description of common ultrasound findings.
Erameh CO, Koch T, Edeawe OI, Oestereich L, Omansen T, Jochum J, Adomeh DI, Ikponmwonsa O, Aire C, Pahlmann M, Asogun DA, Ogbaini-Emovon E, Okogbenin SA, Günther S, Ramharter M, Akideno PE, Kreuels B.
J Infect. 2023 Jul;87(1):27-33. doi: 10.1016/j.jinf.2023.04.008. Epub 2023 Apr 17. PMID: 37075910.
Epidemiology of co-infections in pregnant women living with human immunodeficiency virus 1 in rural Gabon: a cross-sectional study.
Davi SD, Okwu DG, Luetgehetmann M, Abba FM, Aepfelbacher M, Endamne LR, Alabi A, Zoleko-Manego R, Mombo-Ngoma G, Mahmoudou S, Addo MM, Ramharter M, Mischlinger J.
Infect Dis Poverty. 2023 Jul 6;12(1):64. doi: 10.1186/s40249-023-01114-y. PMID: 37408012; PMCID: PMC10324149.
Impact of antibiotic intake on the incidence of extended-spectrum β-lactamase-producing Enterobacterales in sub-Saharan Africa: results from a community-based longitudinal study
Heinemann M, Kleinjohann L, Rolling T, Winter D, Hackbarth N, Ramharter M, Addo M, Eibach D, Phillips RO, Owusu-Ofori A, Vinnemeier CD.
Clin Microbiol Infect. 2023 Mar;29(3):340-345. doi: 10.1016/j.cmi.2022.09.008. Epub 2022 Sep 20. PMID: 36150674.
Comparison of the Diagnostic Accuracy of Three Real-Time PCR Assays for the Detection of Arcobacter butzleri in Human Stool Samples Targeting Different Genes in a Test Comparison without a Reference Standard.
Binder R, Hahn A, Eberhardt KA, Hagen RM, Rohde H, Loderstädt U, Feldt T, Sarfo FS, Di Cristanziano V, Kahlfuss S, Frickmann H, Zautner AE.
Microorganisms. 2023 May 17;11(5):1313. doi: 10.3390/microorganisms11051313. PMID: 37317286; PMCID: PMC10223941.
Investigation on birth weight outcomes in schistosomiasis and praziquantel research: a correspondence.
Holtfreter MC, Mischlinger J, Davi SD, Schleenvoigt BT.
Eur J Med Res. 2023 Jul 12;28(1):231. doi: 10.1186/s40001-023-01202-7. PMID: 37434209; PMCID: PMC10337156.
Tecovirimat therapy for severe monkeypox infection: Longitudinal assessment of viral titers and clinical response pattern-A first case-series experience.
Hermanussen L, Grewe I, Tang HT, Nörz D, Bal LC, Pfefferle S, Unger S, Hoffmann C, Berzow D, Kohsar M, Aepfelbacher M, Lohse AW, Addo MM, Lütgehetmann M, Schulze Zur Wiesch J, Schmiedel S.
J Med Virol. 2023 Jan;95(1):e28181. doi: 10.1002/jmv.28181. Epub 2022 Oct 20. PMID: 36177717.
Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study
Krumkamp R, Kohsar M, Nolte K, Hogan B, Eibach D, Jaeger A, Akenten CW, Drosten C, Boahen KG, Sarpong N, Eckerle I, Binger T, Owusu-Dabo E, May J, Kreuels B.
Sci Rep. 2023 Feb 10;13(1):2443. doi: 10.1038/s41598-023-29410-5. PMID: 36765075; PMCID: PMC9916495.
Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.
Gansane A, Lingani M, Yeka A, Nahum A, Bouyou-Akotet M, Mombo-Ngoma G, Kaguthi G, Barceló C, Laurijssens B, Cantalloube C, Macintyre F, Djeriou E, Jessel A, Bejuit R, Demarest H, Marrast AC, Debe S, Tinto H, Kibuuka A, Nahum D, Mawili-Mboumba DP, Zoleko-Manego R, Mugenya I, Olewe F, Duparc S, Ogutu B.
Malar J. 2023 Jan 3;22(1):2. doi: 10.1186/s12936-022-04420-2. PMID: 36597076; PMCID: PMC9809015.
Loiasis – An extremely neglected tropical disease
Saskia Dede Davi, Michael Ramharter, Tamara Nordmann.
Flugmedizin · Tropenmedizin · Reisemedizin - FTR 2023; 30(01): 15-19, DOI: 10.1055/a-1999-1821
Absence of Malaria-Associated Coagulopathy in Asymptomatic Plasmodium falciparum Infection: Results From a Cross-sectional Study in the Ashanti Region, Ghana.
Rolling CC, Phillips RO, Abass KM, Ken Adu Poku J, Osei-Mireku S, Osei-Wusu B, Thompson W, Vinnemeier CD, Huebl L, Langer F, Francke P, Kuta P, Konrath S, Renné T, Tannich E, Rolling T, Heinemann M.
Open Forum Infect Dis. 2023 Feb 18;10(3):ofad074. doi: 10.1093/ofid/ofad074. PMID: 36968961; PMCID: PMC10034594.
Asymptomatic Gabonese Adults – A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga Weyat LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R
Available at SSRN: https://ssrn.com/abstract=4387200 or http://dx.doi.org/10.2139/ssrn.4387200
Knowledge, attitudes, behaviors, and serological status related to Chagas disease among Latin American migrants in Germany: A cross-sectional study in six German cities.
Wirth M, Gálvez RI, Jochum J, Strauss R, Kristensen K, Stich A, Stegemann M, Stahl P, Puchner KP, Strasen J, Parisi S, Braasch T, Bender M, Hörning A, Hanke M, Störk S, Jacobs T, Pritsch M, Zoller T.
Front Cell Infect Microbiol. 2023 Jan 25;12:1047281. doi: 10.3389/fcimb.2022.1047281
High burden of RSV and influenza in patients presenting with suspected pneumonia in the emergency room of a German tertiary hospital in fall of 2022.
Ettemeyer M, Florey M, Tanida K, Jochum J, Schulze-Sturm U, Lütgehetmann M, Baehr M, Addo MM, Schmiedel S, Rohde H, Koch T.
Infection. 2023 Oct;51(5):1569-1575. doi: 10.1007/s15010-023-02069-w
Treatment and Concomitant Infections in Refugees From the Ukraine With HIV.
Matthews H, Koval A, Völker K, Hertling S, Hoffmann C, Schäfer G, Unger S, Schulze Zur Wiesch J, Hüfner AD, Jordan S, Degen O, Schmiedel S.
Dtsch Arztebl Int. 2023 Aug 7;120(31-32):540-541. doi: 10.3238/arztebl.m2023.0110. PMID: 37721143; PMCID: PMC10534132.
Tecovirimat for the treatment of severe Mpox in Germany.
Hermanussen L, Brehm TT, Wolf T, Boesecke C, Schlabe S, Borgans F, Monin MB, Jensen BO, Windhaber S, Scholten S, Jordan S, Lütgehetmann M, Wiesch JSZ, Addo MM, Mikolajewska A, Niebank M, Schmiedel S.
Infection. 2023 Oct;51(5):1563-1568. doi: 10.1007/s15010-023-02049-0. Epub 2023 Jun 5. PMID: 37273167; PMCID: PMC10240449.
Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection.
Cords L, Woost R, Kummer S, Brehm TT, Kluge S, Schmiedel S, Jordan S, Lohse AW, Altfeld M, Addo MM, Schulze Zur Wiesch J, Beisel C.
Cytokine. 2023 Feb;162:156109. doi: 10.1016/j.cyto.2022.156109. Epub 2022 Dec 13. PMID: 36529029; PMCID: PMC9744680.
Clinical Characteristics and Outcomes Among Travelers With Severe Dengue : A GeoSentinel Analysis.
Huits R, Angelo KM, Amatya B, Barkati S, Barnett ED, Bottieau E, Emetulu H, Epelboin L, Eperon G, Medebb L, Gobbi F, Grobusch MP, Itani O, Jordan S, Kelly P, Leder K, Díaz-Menéndez M, Okumura N, Rizwan A, Rothe C, Saio M, Waggoner J, Yoshimura Y, Libman M, Hamer DH, Schwartz E.
Ann Intern Med. 2023 Jul;176(7):940-948. doi: 10.7326/M23-0721. Epub 2023 Jun 20. Erratum in: Ann Intern Med. 2023 Jul 18;: Erratum in: Ann Intern Med. 2023 Sep;176(9):1288. PMID: 37335991.
Prospective Single-Center Cohort Study on HIV Pre-exposure Prophylaxis Reveals Transient but Relevant
Weimann L, Schäfer G, Matthews H, Florey M, Scheiter R, Hüfner A, Jordan S, Grenz M, Schmiedel S, Schulze Zur Wiesch J, Degen O, Koch T.
J Acquir Immune Defic Syndr. 2023 May 1;93(1):e1-e3. doi: 10.1097/QAI.0000000000003170. PMID: 36881817.
Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study.
Woo MS, Brehm TT, Fischer M, Heyer A, Wichmann D, Jordan S, Nörz D, Lütgehetmann M, Addo MM, Lohse AW, Schmiedel S, Kluge S, Schulze Zur Wiesch J.
Microbiol Spectr. 2023 Feb 14;11(1):e0410322. doi: 10.1128/spectrum.04103-22. Epub 2022 Dec 8. PMID: 36475890; PMCID: PMC9927465.
CMV-IgG pre-allogeneic hematopoietic stem cell transplantation and the risk for CMV reactivation and mortality.
Eberhardt KA, Jung V, Knops E, Heger E, Wirtz M, Steger G, Kaiser R, Affeldt P, Holtick U, Klein F, Scheid C, Di Cristanziano V.
Bone Marrow Transplant. 2023 Jun;58(6):639-646. doi: 10.1038/s41409-023-01944-2. Epub 2023 Mar 3. PMID: 36869190; PMCID: PMC10247370.
Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-19.
Thibeault C, Bardtke L, Vanshylla K, di Cristanziano V, Eberhardt KA, Stubbemann P, Hillus D, Tober-Lau P, Mukherjee P, Münn F, Lippert LJ, Helbig ET, Lingscheid T, Steinbeis F, Mittermaier M, Witzenrath M, Zoller T; Pa-COVID study group; Klein F, Sander LE, Kurth F.
JCI Insight. 2023 Apr 24;8(8):e166711. doi: 10.1172/jci.insight.166711. PMID: 36881474; PMCID: PMC10243822.
Screening for Resistant Bacteria, Antimicrobial Resistance Genes, Sexually Transmitted Infections and Schistosoma spp. in Tissue Samples from Predominantly Vaginally Delivered Placentae in Ivory Coast and Ghana.
Franz R, Hahn A, Hagen RM, Rohde H, Eberhardt KA, Ehrhardt S, Baum J, Claussen L, Feldt T, Hinz R, Barthel D, Bindt C, Tagbor H, Nguah SB, Koffi M, Köller T, Warnke P, Pankok F, Taudien S, Frickmann H, Schoppen S.
Pathogens. 2023 Jul 30;12(8):999. doi: 10.3390/pathogens12080999. PMID: 37623959; PMCID: PMC10459482.
Very low prevalence of Mansonella perstans-specific cell-free DNA in serum samples of Ghanaian HIV patients.
Eberhardt KA, Veletzky L, Weinreich F, Phillips RO, Sarfo FS, Feldt T, Dompreh A, Asibey SO, Boateng R, Frickmann H.
Eur J Microbiol Immunol (Bp). 2023 Sep 26. doi: 10.1556/1886.2023.00028. Epub ahead of print. PMID: 37751320.
. 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
Bosquillon de Jarcy L, Akbil B, Mhlekude B, Leyens J, Postmus D, Harnisch G, Jansen J, Schmidt ML, Aigner A, Pott F, Chua RL, Krist L, Gentile R, Mühlemann B, Jones TC, Niemeyer D, Fricke J, Keil T, Pischon T, Janke J, Conrad C, Iacobelli S, Drosten C, Corman VM, Ralser M, Eils R, Kurth F, Sander L, Goffinet C.
Clin Exp Med. 2023 May 10:1–12. doi: 10.1007/s10238-023-01077-2. Epub ahead of print. PMID: 37162650; PMCID: PMC10170455.
Interoperable, Domain-Specific Extensions for the German Corona Consensus (GECCO) COVID-19 Research Data Set Using an Interdisciplinary, Consensus-Based Workflow: Data Set Development Study
Lichtner G, Haese T, Brose S, Röhrig L, Lysyakova L, Rudolph S, Uebe M, Sass J, Bartschke A, Hillus D, Kurth F, Sander LE, Eckart F, Toepfner N, Berner R, Frey A, Dörr M, Vehreschild JJ, von Kalle C, Thun S.
JMIR Med Inform. 2023 Jul 18;11:e45496. doi: 10.2196/45496. PMID: 37490312; PMCID: PMC10368099.
Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis.
WorldWide Antimalarial Resistance Network White Blood Cell Count in Malaria Study Group.
Malar J. 2023 Jun 6;22(1):174. doi: 10.1186/s12936-023-04583-6. PMID: 37280686; PMCID: PMC10243075.
Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure.
Dietz J, Müllhaupt B, Buggisch P, Graf C, Peiffer KH, Matschenz K, Schattenberg JM, Antoni C, Mauss S, Niederau C, Discher T, Trauth J, Dultz G, Schulze Zur Wiesch J, Piecha F, Klinker H, Müller T, Berg T, Neumann-Haefelin C, Berg CP, Zeuzem S, Sarrazin C; German HCV Resistance Study Group; University Hospitals; Academic Hospitals; Local study sites (private practices), Germany.
Hepatol. 2023 Jan;78(1):57-66. doi: 10.1016/j.jhep.2022.08.016. Epub 2022 Aug 27. PMID: 36031158.
Asymptomatic arbovirus and campylobacter infections in German travelers to Asia.
Dammermann W, Haller IE, Singethan K, Vinnemeier CD, Hentschel F.
Arch Virol. 2023 Sep 20;168(10):254. doi: 10.1007/s00705-023-05870-y. PMID: 37728769; PMCID: PMC10511557.
Community health workers in clinical research at the example of a phase IIIb/ IV antimalarial drug trial conducted in five African countries.
Groger M, Lutete GT, Assi SB, Bigoga JD, Ntamabyaliro NY, Arbe-Barnes S, Shin J, Adegnika AA, Ntoumi F, Kremsner PG, Ramharter M, Duparc S, Borghini-Fuhrer I, Mombo-Ngoma G.
Int J Infect Dis. 2023 Dec;137:114-117. doi: 10.1016/j.ijid.2023.10.016
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R.
EBioMedicine. 2023 Nov;97:104814. doi: 10.1016/j.ebiom.2023.104814.
Investigation on birth weight outcomes in schistosomiasis and praziquantel research: a correspondence.
Holtfreter MC, Mischlinger J, Davi SD, Schleenvoigt BT.
Eur J Med Res. 2023 Jul 12;28(1):231. doi: 10.1186/s40001-023-01202-7. PMID: 37434209; PMCID: PMC10337156.
Tecovirimat therapy for severe monkeypox infection: Longitudinal assessment of viral titers and clinical response pattern-A first case-series experience.
Hermanussen L, Grewe I, Tang HT, Nörz D, Bal LC, Pfefferle S, Unger S, Hoffmann C, Berzow D, Kohsar M, Aepfelbacher M, Lohse AW, Addo MM, Lütgehetmann M, Schulze Zur Wiesch J, Schmiedel S.
J Med Virol. 2023 Jan;95(1):e28181. doi: 10.1002/jmv.28181. Epub 2022 Oct 20. PMID: 36177717.
Community health workers in clinical research at the example of a phase IIIb/ IV antimalarial drug trial conducted in five African countries
Mirjam Groger, Gaston Tona Lutete, Serge-Brice Assi, Jude D Bigoga, Nsengi Y Ntamabyaliro, Sarah Arbe-Barnes, Jangsik Shin, Ayola A Adegnika, Francine Ntoumi, Peter G Kremsner, Michael Ramharter, Stephan Duparc, Isabelle Borghini-Fuhrer, Ghyslain Mombo-Ngoma
Int J Infect Dis . 2023 Dec:137:114-117. doi: 10.1016/j.ijid.2023.10.016. Epub 2023 Oct 21.
Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial
Mirjam Groger, Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Nsengi Y Ntamabyaliro, Gauthier Kahunu Mesia, Trésor Bodjick Muena Mujobu, Lia Betty Dimessa Mbadinga, Rella Zoleko Manego, Diane Egger-Adam, Isabelle Borghini-Fuhrer, Jangsik Shin, Robert Miller, Sarah Arbe-Barnes, Stephan Duparc, Michael Ramharter
Lancet Microbe . 2022 May 30;S2666-5247(22)00092-1. doi: 10.1016/S2666-5247(22)00092-1. Online ahead of print.
Challenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria
Bassat Q, Maïga-Ascofaré O, May J, Clain J, Mombo-Ngoma G, Groger M, Adegnika AA, Agobé JD, Djimde A, Mischlinger J, Ramharter M; ASAAP and Multimal Consortia.
Malar J. 2022 Feb 22;21(1):61. doi: 10.1186/s12936-022-04079-9. PMID: 35193586; PMCID: PMC8864855.
Drug-induced hypersensitivity to artemisinin-based therapies for malaria
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol . 2022 Feb;38(2):136-146. doi: 10.1016/j.pt.2021.08.011. Epub 2021 Sep 21.
Pharmacokinetics of ribavirin in the treatment of Lassa fever: An observational clinical study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.
Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C.
Clin Infect Dis. 2022 Jul 26:ciac578. doi: 10.1093/cid/ciac578. Epub ahead of print. PMID: 35881530. (open access)
Multicentric Evaluation of SeeGene Allplex Real-Time PCR Assays Targeting 28 Bacterial, Microsporidal and Parasitic Nucleic Acid Sequences in Human Stool Samples.
Weinreich F, Hahn A, Eberhardt KA, Kann S, Köller T, Warnke P, Dupke S, Dekker D, May J, Frickmann H, Loderstädt U.
Diagnostics (Basel). 2022 Apr 16;12(4):1007. doi: 10.3390/diagnostics12041007.
Psychomotor development in two-year-old Ivorian and Ghanaian children - Psychometric properties of the Kilifi Developmental Inventory.
Barthel D, Kriston L, Yao ED, Fordjour D, Armel KEJ, Eberhardt KA, Hinz R, Ehrhardt S, Bindt C; International CDS Study Group.
Br J Dev Psychol. 2022 Jul 15. doi: 10.1111/bjdp.12428.
Treatment Failure in Vertebral Osteomyelitis - Is it all about Staphylococcus aureus?
Yagdiran A, Jochimsen D, Kernich N, Herden J, Eysel P, Eberhardt KA, Jung N.
Spine (Phila Pa 1976). 2022 Jul 15. doi: 10.1097/BRS.0000000000004420.
Comparative Evaluation of Real-Time Screening PCR Assays for Giardia duodenalis and of Assays Discriminating the Assemblages A and B.
Weinreich F, Hahn A, Eberhardt KA, Kann S, Feldt T, Sarfo FS, Di Cristanziano V, Frickmann H, Loderstädt U.
Microorganisms. 2022 Jun 28;10(7):1310. doi: 10.3390/microorganisms10071310.
The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana.
Sarfo FS, Dompreh A, Asibey SO, Boateng R, Weinreich F, Kuffour EO, Norman B, Di Cristanziano V, Frickmann H, Feldt T, Eberhardt KA.
Microorganisms. 2022 Jul 13;10(7):1407. doi: 10.3390/microorganisms10071407.
Screening for Schistosoma spp. and Leishmania spp. DNA in Serum of Ghanaian Patients with Acquired Immunodeficiency.
Weinreich F, Hahn A, Hagen RM, Rohde H, Sarfo FS, Feldt T, Dompreh A, Asibey SO, Boateng R, Frickmann H, Eberhardt KA.
Pathogens. 2022 Jul 2;11(7):760. doi: 10.3390/pathogens11070760.
Performance of Field's Stain Compared with Conventional Giemsa Stain for the Rapid Detection of Blood Microfilariae in Gabon.
Mbassi FE, Mombo-Ngoma G, Ndoumba WN, Yovo EK, Eberhardt KA, Mbassi DE, Adegnika AA, Agnandji ST, Bouyou-Akotet MK, Ramharter M, Zoleko-Manego R.
Am J Trop Med Hyg. 2022 Jul 5:tpmd220061. doi: 10.4269/ajtmh.22-0061.
Malaria and its importance in travel medicine
Mischlinger J, Jochum J, Ramharter M, Kurth F.
Dtsch Med Wochenschr. 2022 Jun;147(12):745-755. doi: 10.1055/a-1661-3783. Epub 2022 Jun 7. PMID: 35672022
Leishmania infantum reactivation with secondary IgA nephropathy.
Grewe I, Brehm TT, Kreuels B, Steinmetz OM, Dumoulin B, Asemissen AM, Tappe D, Ramharter M, Schmiedel S.
J Travel Med. 2022 Mar 14:taac038. doi: 10.1093/jtm/taac038. Online ahead of print. PMID: 35285886
Corrigendum to: Molecular Epidemiology of Mansonella Species in Gabon.
Sandri TL, Kreidenweiss A, Cavallo S, Weber D, Juhas S, Rodi M, Woldearegai TG, Gmeiner M, Veletzky L, Ramharter M, Tazemda-Kuitsouc GB, Matsiegui PB, Mordmüller B, Held J.
J Infect Dis. 2022 Mar 2;225(5):929. doi: 10.1093/infdis/jiab439. PMID: 35106595
Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis.
Hotz JF, Kaczirek K, Stremitzer S, Waneck F, Auer H, Perkmann T, Kussmann M, Bauer PK, Chen RY, Kriz R, Burgmann H, Ramharter M, Lagler H.
Pathogens. 2022 Feb 18;11(2):261. doi: 10.3390/pathogens11020261. PMID: 35215203
Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project).
González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C.
BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197. PMID: 34815285
Correction: Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma.
Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A.
2022 Jun 2;16(6):e0010512. doi: 10.1371/journal.pntd.0010512. eCollection 2022 Jun. PMID: 35653329
A standardised Phase III clinical trial framework to assess therapeutic interventions for Lassa fever.
Olayinka AT, Bourner J, Akpede GO, Okoeguale J, Abejegah C, Ajayi NA, Akude C, Ayodeji O, Bausch DG, de Clerck H, Dan-Nwafor C, Dunning J, Erameh C, Eze JN, Formenty P, Gillesen A, Jalloh S, Jaspard M, Jegede T, Maikere J, Malvy D, Ogbaini-Emovon E, Ojo OE, Okogbenin S, O'Neill K, Orji ML, Owhin SO, Ramharter M, Samuels RJ, Shehu N, Merson L, Salam AP, Kayem ND, Horby P, Ihekweazu C, Olliaro P.
PLoS Negl Trop Dis. 2022 Jan 6;16(1):e0010089. doi: 10.1371/journal.pntd.0010089. eCollection 2022 Jan. PMID: 34990453
Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambaréné, Gabon.
Essone PN, Adegbite BR, Mbadinga MJM, Mbouna AV, Lotola-Mougeni F, Alabi A, Edoa JR, Lell B, Alabi AS, Adegnika AA, Ramharter M, Siawaya JFD, Grobusch MP, Kremsner PG, Agnandji ST.
Infection. 2022 Aug;50(4):897-905. doi: 10.1007/s15010-022-01760-8. Epub 2022 Feb 8. PMID: 35133607
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M.
Eur J Immunol. 2022 Feb;52(2):312-327. doi: 10.1002/eji.202149424. Epub 2021 Nov 25. PMID: 34752634
Attitudes, practices, and obstacles towards influenza vaccination for international travelers among travel health advisors in Germany: A questionnaire-based survey.
Brehm TT, Jordan S, Addo MM, Ramharter M, Kreuels B.
Travel Med Infect Dis. 2022 Jan-Feb;45:102233. doi: 10.1016/j.tmaid.2021.102233. Epub 2021 Dec 8. PMID: 34890809
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis.
(Ramharter) WorldWide Antimalarial Resistance Network Methodology Study Group.
Malar J. 2022 Mar 24;21(1):106. doi: 10.1186/s12936-021-03980-z. PMID: 35331243
Deciphering the Plasmodium falciparum malaria-specific CD4+ T-cell response: ex vivo detection of high frequencies of PD-1+TIGIT+ EXP1-specific CD4+ T cells using a novel HLA-DR11-restricted MHC class II tetramer.
Schulte S, Heide J, Ackermann C, Peine S, Ramharter M, Mackroth MS, Woost R, Jacobs T, Schulze Zur Wiesch J.
Clin Exp Immunol. 2022 Apr 4;207(2):227-236. doi: 10.1093/cei/uxab027. PMID: 35020841
Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data.
(Ramharter) WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group.
BMC Med. 2022 Mar 7;20(1):85. doi: 10.1186/s12916-022-02265-9. PMID: 35249546
Risk-adjusted active tuberculosis case finding strategy in central Ethiopia.
Fuchs A, Tufa TB, Pfäfflin F, Schönfeld A, Nordmann T, Melaku F, Sorsa A, Orth HM, Häussinger D, Luedde T, Feldt T.
IJID Reg. 2022 Mar 20;3:196-203. doi: 10.1016/j.ijregi.2022.03.012. PMID: 35755475; PMCID: PMC9216629.
Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia.
Tufa TB, Mackenzie CR, Orth HM, Wienemann T, Nordmann T, Abdissa S, Hurissa Z, Schönfeld A, Bosselmann M, Häussinger D, Pfeffer K, Luedde T, Fuchs A, Feldt T.
Antimicrob Resist Infect Control. 2022 Jan 15;11(1):8. doi: 10.1186/s13756-022-01053-7. PMID: 35033191; PMCID: PMC8761287.
Parasites - important endemic and imported pathogens.
Jordan S, Kreuels B.
Dtsch Med Wochenschr. 2022 Jun;147(11):687-696. doi: 10.1055/a-1664-7518. Epub 2022 May 30. PMID: 35636420 Review. German.
Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022.
Nörz D, Pfefferle S, Brehm TT, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp EM, Jordan S, Addo MM, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M, Knobloch JK.
Euro Surveill. 2022 Jun;27(26). doi: 10.2807/1560-7917.ES.2022.27.26.2200477. PMID: 35775427
Imitation eines Felty-Syndroms durch eine viszerale Leishmaniasis bei rheumatoider Arthritis unter Therapie mit Methotrexat und Etanercept.
Ruffer, N., Tomas, N. M., Schmiedel, S., Jordan, S. & Kötter, I.
Z Rheumatol. 2022 Apr;81(3):244. doi: 10.1007/s00393-021-01143-8. PMID: 34932148 German. No abstract available.
Inflammatory cytokine profile and T cell responses in African tick bite fever patients.
Rauch J, Jochum J, Eisermann P, Gisbrecht J, Völker K, Hunstig F, Mehlhoop U, Muntau B, Tappe D.
Med Microbiol Immunol. 2022 Jun;211(2-3):143-152. doi: 10.1007/s00430-022-00738-5. Epub 2022 May 11. PMID: 35543881
High-resolution analysis of individual spike peptide-specific CD4+ T-cell responses in vaccine recipients and COVID-19 patients.
Karsten H, Cords L, Westphal T, Knapp M, Brehm TT, Hermanussen L, Omansen TF, Schmiedel S, Woost R, Ditt V, Peine S, Lütgehetmann M, Huber S, Ackermann C, Wittner M, Addo MM, Sette A, Sidney J, Schulze Zur Wiesch J.
Clin Transl Immunology. 2022 Aug 9;11(8):e1410. doi: 10.1002/cti2.1410. eCollection 2022. PMID: 35957961
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B
PA-COVID-19 Study Group. Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. PMID: 35032429
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.
Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Schommers P, Lehmann C, Kurth F, Sander LE, Klein F.
Nat Med. 2022 Mar;28(3):477-480. doi: 10.1038/s41591-021-01676-0. Epub 2022 Jan 19. PMID: 35046572
Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Respir Med. 2022 Jan;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub 2021 Dec 1. PMID: 34871947
Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections.
Tober-Lau P, Gruell H, Vanshylla K, Koch WM, Hillus D, Schommers P, Suárez I, Suttorp N, Sander LE, Klein F, Kurth F.
Emerg Infect Dis. 2022 May;28(5):1050-1052. doi: 10.3201/eid2805.220271. Epub 2022 Mar 8. PMID: 35259088
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns.
Gruell H, Vanshylla K, Korenkov M, Tober-Lau P, Zehner M, Münn F, Janicki H, Augustin M, Schommers P, Sander LE, Kurth F, Kreer C, Klein F.
Cell Host Microbe. 2022 Jul 7:S1931-3128(22)00318-3. doi: 10.1016/j.chom.2022.07.002. Online ahead of print. PMID: 35921836
Durability of omicron-neutralising serum activity after mRNA booster immunisation in older adults.
Vanshylla K, Tober-Lau P, Gruell H, Münn F, Eggeling R, Pfeifer N, Le NH, Landgraf I, Kurth F, Sander LE, Klein F.
Lancet Infect Dis. 2022 Apr;22(4):445-446. doi: 10.1016/S1473-3099(22)00135-9. Epub 2022 Feb 28. PMID: 35240040
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Degenhardt F, Ellinghaus D, Juzenas S, Kurth F, et al..
Hum Mol Genet. 2022 Jul 15:ddac158. doi: 10.1093/hmg/ddac158. Online ahead of print. PMID: 35848942
Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19.
Vasbinder A, Anderson E, Shadid H, Kurth F, et.al..
Diabetes Care. 2022 Mar 1;45(3):692-700. doi: 10.2337/dc21-2102. PMID: 35045184
The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics.
Schons M, Pilgram L, Reese JP, Stecher M, Kurth F, et al..
NAPKON Research Group. Eur J Epidemiol. 2022 Jul 29:1-22. doi: 10.1007/s10654-022-00896-z. Online ahead of print. PMID: 35904671
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies.
Akbil B, Meyer T, Stubbemann P, Kurth F, et al..
J Clin Immunol. 2022 May 5:1-19. doi: 10.1007/s10875-022-01252-2. Online ahead of print. PMID: 35511314
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. PMID: 34861681
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum R, Suwalski P, Kurth F, et al..
EClinicalMedicine. 2022 Jun;48:101438. doi: 10.1016/j.eclinm.2022.101438. Epub 2022 May 14. PMID: 35600330
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Lingscheid T, Lippert LJ, Hillus D, Kurth F et al..
Infection. 2022 Apr 14:1-12. doi: 10.1007/s15010-022-01796-w. Online ahead of print. PMID: 35420370
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study.
Wang Z, Cryar A, Lemke O, Kurth F, et al..
EClinicalMedicine. 2022 Jul;49:101495. doi: 10.1016/j.eclinm.2022.101495. Epub 2022 Jun 9. PMID: 35702332
A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021.
Wulf Hanson S, Abbafati C, Aerts JG, Al-Aly Z, Kurth F, et al..
medRxiv. 2022 May 27:2022.05.26.22275532. doi: 10.1101/2022.05.26.22275532. Preprint. PMID: 35664995
Attitude toward a mandatory COVID-19 vaccination policy and its determinants: Evidence from serial cross-sectional surveys conducted throughout the pandemic in Germany.
Sprengholz P, Korn L, Eitze S, Felgendreff L, Siegers R, Goldhahn L, De Bock F, Huebl L, Böhm R, Betsch C.
Vaccine. 2022 Feb 7:S0264-410X(22)00130-X. doi: 10.1016/j.vaccine.2022.01.065. Online ahead of print. PMID: 35153092
Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19.
Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, Marget M, Peine S, Johansson AM, Sette A, Lütgehetmann M, Kwok WW, Sidney J, Schulze Zur Wiesch J.
PLoS Pathog. 2022 Jan 5;18(1):e1010220. doi: 10.1371/journal.ppat.1010220. eCollection 2022 Jan. PMID: 34986197
Long-term persistence of antibodies after diphtheria/tetanus vaccination in immunosuppressed patients with inflammatory rheumatic diseases and healthy controls.
Mischlinger J, Jaeger VK, Ciurea A, Gabay C, Hasler P, Mueller RB, Siegrist CA, Villiger P, Walker UA, Hatz C, Bühler S.
Vaccine. 2022 Aug 5;40(33):4897-4904. doi: 10.1016/j.vaccine.2022.06.013. Epub 2022 Jul 7. PMID: 35810064
Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells.
Dalimot JJ, Klei TRL, Beuger BM, Dikmen Z, Bouwman SAM, Mombo-Ngoma G, Zoleko-Manego R, Ndzebe-Ndoumba WF, Egée S, Kuijpers TW, Grobusch MP, van Bruggen R.
Blood Adv. 2022 Mar 29:bloodadvances.2021006171. doi: 10.1182/bloodadvances.2021006171. Online ahead of print. PMID: 35349634
Drug-induced hypersensitivity to artemisinin-based therapies for malaria.
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol . 2022 Feb;38(2):136-146. doi: 10.1016/j.pt.2021.08.011.
Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study.
Zoleko-Manego R, Okwu DG, Handrich C, Dimessa-Mbadinga LB, Akinosho MA, Ndzebe-Ndoumba WF, Davi SD, Stelzl D, Veletzky L, Kreidenweiss A, Nordmann T, Adegnika AA, Lell B, Kremsner PG, Ramharter M, Mombo-Ngoma G.
PLoS Negl Trop Dis . 2022 Oct 31;16(10):e0010899.
Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections.
Okogbenin S, Erameh C, Okoeguale J, Edeawe O, Ekuaze E, Iraoyah K, Agho J, Groger M, Kreuels B, Oestereich L, Babatunde FO, Akhideno P, Günther S, Ramharter M, Omansen T.
Emerg Infect Dis. 2022 Oct;28(10):2060-2063. doi: 10.3201/eid2810.220625. PMID: 36148915; PMCID: PMC9514364.
Alveolar echinococcosis in immunocompromised hosts.
Autier B, Gottstein B, Millon L, Ramharter M, Gruener B, Bresson-Hadni S, Dion S, Robert-Gangneux F.
Clin Microbiol Infect. 2022 Dec 14:S1198-743X(22)00630-9. doi: 10.1016/j.cmi.2022.12.010. Online ahead of print. PMID: 36528295
Leishmania infantum reactivation with secondary IgA nephropathy
Grewe I, Brehm TT, Kreuels B, Steinmetz OM, Dumoulin B, Asemissen AM, Tappe D, Ramharter M, Schmiedel S.
J Travel Med. 2022 Nov 4;29(7):taac038. doi: 10.1093/jtm/taac038. PMID: 35285886
Impact of antibiotic intake on incidence of extended spectrum beta-lactamase producing Enterobacterales in sub-Saharan Africa - results from a community-based longitudinal study.
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Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial.
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Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
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Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
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Hum Mol Genet. 2022 Nov 28;31(23):3945-3966. doi: 10.1093/hmg/ddac158. PMID: 35848942
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Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. doi: 10.1128/aac.01229-22. Epub 2022 Oct 26. PMID: 36286542
Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.
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Neutralisation sensitivity of the SARS-CoV-2 omicron BA.2.75 sublineage.
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Lancet Infect Dis. 2022 Oct;22(10):1422-1423. doi: 10.1016/S1473-3099(22)00580-1. Epub 2022 Sep 6. PMID: 36084664
Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents.
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Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells.
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Neuevaluierung der Ribavirintherapie bei Lassafieber. Pharmakokinetik von Ribavirin bei Lassafieber.
Christine J. Kleist , Mirjam Groger
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Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study
Jonas Früh, Andre Fuchs, Tafese Beyene Tufa, Loraine Früh, Zewdu Hurissa, Hans Martin Orth, Johannes Georg Bode, Kirsten Alexandra Eberhardt, Dieter Häussinger, Torsten Feldt
PLoS One . 2021 Feb 4;16(2):e0245496. doi: 10.1371/journal.pone.0245496. eCollection 2021.
Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses
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Full text links full text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles References MeSH terms Substances Supplementary concepts Related information LinkOut - more resources Front Immunol . 2021 Jan 29;11:628971. doi: 10.3389/fimmu.2020.628971. eCollection 2020.
Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells
Merryn Fraser, Weidong Jing, Stefan Bröer, Florian Kurth, Leif-Erik Sander, Kai Matuschewski, Alexander G. Maier.
PLoS Pathog . 2021 Feb 18;17(2):e1009259. doi: 10.1371/journal.ppat.1009259. eCollection 2021 Feb.
Birth weight, growth, nutritional status and mortality of infants from Lambare´ne´ and Fougamou in Gabon in their first year of life
Rella Zoleko-Manego, Johannes Mischlinger, Jean Claude Dejon-Agobé, Arti Basra, J Rodolphe Mackanga, Daisy Akerey Diop, Ayola Akim Adegnika, Selidji T Agnandji, Bertrand Lell, Peter G Kremsner, Pierre Blaise Matsiegui, Raquel González, Clara Menendez, Michael Ramharter, Ghyslain Mombo-Ngoma.
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Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG
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Trop Med Int Health . 2021 Apr 15. doi: 10.1111/tmi.13591. Online ahead of print.
Less than you'd think-a prospective study on MRSA-colonization in healthy travellers
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J Travel Med . 2021 Apr 14;28(3):taaa242. doi: 10.1093/jtm/taaa242.
A call to caution when hydroxychloroquine is given to elderly patients with COVID-19.
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Int J Infect Dis. 2021 Apr 10;106:265-268. doi: 10.1016/j.ijid.2021.04.009. Online ahead of print. PMID: 33848675
Malaria in the Time of COVID-19: Do Not Miss the Real Cause of Illness.
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Clin Infect Dis. 2021 Jan 28:ciaa1942. doi: 10.1093/cid/ciaa1942. Online ahead of print. PMID: 33506270
Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon
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COVID-19 Vaccine Acceptance, Barriers and Facilitators among Healthcare Workers in Pakistan
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Journal of Infectious Diseases & Therapy, Preprint from Research Square, 19 Apr 2021 DOI: 10.21203/rs.3.rs-431543/v1 PPR: PPR313640
Comparative Assessment of In-House Real-Time PCRs Targeting Enteric Disease-Associated Microsporidia in Human Stool Samples
Tanida, K.; Hahn, A.; Eberhardt, K.A.; Tannich, E.; Landt, O.; Kann, S.; Feldt, T.; Sarfo, F.S.; Di Cristanziano, V.; Frickmann, H.; Loderstädt, U.
Pathogens. 2021; 10(6):656. https://doi.org/10.3390/pathogens10060656
Psychometric properties of the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) in two-year-old Ivorian and Ghanaian children
Dana Barthel, Levente Kriston, Nan Guo, Esther Doris Yao, Koffi Ekissi Jean Armel, Daniel Fordjour, Yasmin Mohammed, Carine Esther Bony Kotchi, Kirsten Alexandra EberhardtORCID Icon, Rebecca Hinz, Stephan Ehrhardt & Carola Bindt
Applied Developmental Science. 2021 Jun 3; https://doi.org/10.1080/10888691.2021.1931216
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
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Nat Biotechnol. 2020 Dec 24. doi: 10.1038/s41587-020-00796-1. Online ahead of print.PMID: 33361824
Paediatric formulations of artemisinin-based combination therapies for treating uncomplicated malaria in children.
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A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.
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J Infect Dis . 2021 Jan 4;223(1):10-14. doi: 10.1093/infdis/jiaa623.
Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021
Tober-Lau P, Schwarz T, Hillus D, Spieckermann J, Helbig ET, Lippert LJ, Thibeault C, Koch W, Bergfeld L, Niemeyer D, Muhlemann B, Conrad C, Kasper S, Munn F, Kunitz F, Jones TC, Suttorp N, Drosten C, Sander LE, Kurth F, Corman VM.
Emerg Infect Dis . 2021 Aug;27(8):2169-2173. doi: 10.3201/eid2708.210887. Epub 2021 Jun 8.
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study
Thibeault C, Muhlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Muller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE, Pa CSG, Corman VM, Kurth F.
Infection . 2021 Aug;49(4):703-714. doi: 10.1007/s15010-021-01594-w. Epub 2021 Apr 22.
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany.
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Emerg Infect Dis . 2021 Aug;27(8):2174-2178. doi: 10.3201/eid2708.211145. Epub 2021 Jun 8.
SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients.
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Front Immunol . 2021 Mar 23;12:629185. doi: 10.3389/fimmu.2021.629185. eCollection 2021.
Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis.
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Front Immunol . 2021 Jun 30;12:690698. doi: 10.3389/fimmu.2021.690698. eCollection 2021.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
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Eur Respir J . 2021 Mar 11;57(3):2002384. doi: 10.1183/13993003.02384-2020. Print 2021 Mar.
Ultra-fast proteomics with Scanning SWATH.
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Nat Biotechnol . 2021 Jul;39(7):846-854. doi: 10.1038/s41587-021-00860-4. Epub 2021 Mar 25.
Estimating infectiousness throughout SARS-CoV-2 infection course.
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Science . 2021 Jul 9;373(6551):eabi5273. doi: 10.1126/science.abi5273. Epub 2021 May 25.
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.
Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J, Group ECS, Klein F, Kurth F, Corman VM, Sander LE.
Lancet Respir Med . 2021 Aug 12;S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X.
. Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Muhlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Muller MA, Pa C-csg, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F.
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Collaborators SA-C-TiES. A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.
Hicks SM, Pohl K, Neeman T, McNamara HA, Parsons KM, He JS, Ali SA, Nazir S, Rowntree LC, Nguyen THO, Kedzierska K, Doolan DL, Vinuesa CG, Cook MC, Coatsworth N, Myles PS, Kurth F, Sander LE, Mann GJ, Gruen RL, George AJ, Gardiner EE, Cockburn IA.
Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells.
Fraser M, Jing W, Broer S, Kurth F, Sander LE, Matuschewski K, Maier AG.
PLoS Pathog . 2021 Feb 18;17(2):e1009259. doi: 10.1371/journal.ppat.1009259. eCollection 2021 Feb.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity.
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glosenkamp C, Muller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hubner RH.
Infection . 2021 Aug;49(4):757-762. doi: 10.1007/s15010-021-01606-9. Epub 2021 Apr 6.
A time-resolved proteomic and prognostic map of COVID-19.
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Cell Syst . 2021 Aug 18;12(8):780-794.e7. doi: 10.1016/j.cels.2021.05.005. Epub 2021 Jun 14.
Echocardiographic Evaluation of Right Ventricular (RV) Performance over Time in COVID-19-Associated ARDS-A Prospective Observational Study.
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Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
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Science . 2021 Oct 8;374(6564):eabh1823. doi: 10.1126/science.abh1823. Epub 2021 Oct 8.
Hookworm infection in returning travellers and migrants: a 10-year case series at a German center for tropical medicine.
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Selbst eingeschätzte medizinische Versorgung im Verlauf der SARS-CoV-2-Pandemie in Deutschland: Ergebnisse der COSMO-Studie.
Heidemann C, Paprott R, Huebl L, Scheidt-Nave C, Reitzle L.
Postponed Dental Visits during the COVID-19 Pandemic and their Correlates. Evidence from the Nationally Representative COVID-19 Snapshot Monitoring in Germany (COSMO).
Hajek A, De Bock F, Huebl L, Kretzler B, König HH.
Healthcare (Basel) . 2021 Jan 5;9(1):50. doi: 10.3390/healthcare9010050.
Physical Activity during COVID-19 in German Adults: Analyses in the COVID-19 Snapshot Monitoring Study (COSMO).
Maertl T, De Bock F, Huebl L, Oberhauser C, Coenen M, Jung-Sievers C, On Behalf Of The Cosmo Study Team.
Int J Environ Res Public Health . 2021 Jan 9;18(2):507. doi: 10.3390/ijerph18020507.
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Recurrent Swelling and Microfilaremia Caused by Dirofilaria repens Infection after Travel to India.
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Perceived Access to Health Care Services and Relevance of Telemedicine during the COVID-19 Pandemic in Germany.
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Determinants of Postponed Cancer Screening During the COVID-19 Pandemic: Evidence from the Nationally Representative COVID-19 Snapshot Monitoring in Germany (COSMO).
Hajek A, De Bock F, Huebl L, Kretzler B, König HH.
Risk Manag Healthc Policy . 2021 Jul 14;14:3003-3011. doi: 10.2147/RMHP.S297326. eCollection 2021.
Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy.
Mischlinger J, Manego RZ, Mombo-Ngoma G, Ekoka Mbassi D, Hackbarth N, Ekoka Mbassi FA, Davi SD, Kreuzmair R, Veletzky L, Hergeth J, Ndoumba WN, Pitzinger P, Groger M, Matsiegui PB, Adegnika AA, Agnandji ST, Lell B, Ramharter M.
PLoS Negl Trop Dis . 2021 Aug 16;15(8):e0009623. doi: 10.1371/journal.pntd.0009623. eCollection 2021 Aug.
Quantification of the Proportion of Unfavorable Clinical Outcomes among Imported Malaria Patients According to the Degree of Semi-Immunity on Population Level: An Ecological Study.
Nordmann T, Davi SD, Ramharter M, Mischlinger J.
Am J Trop Med Hyg . 2021 Jun 14;105(2):477-479. doi: 10.4269/ajtmh.21-0196.
Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study.
Früh J, Fuchs A, Tufa TB, Früh L, Hurissa Z, Orth HM, Bode JG, Eberhardt KA, Häussinger D, Feldt T.
PLoS One . 2021 Feb 4;16(2):e0245496. doi: 10.1371/journal.pone.0245496. eCollection 2021.
Detection of SARS-CoV-2 viremia before onset of COVID-19 symptoms in an allo-transplanted patient with acute leukemia.
Di Cristanziano V*, Meyer-Schwickerath C*, Eberhardt KA*, Rybniker J, Heger E, Knops E, Hallek M, Klein F, Holtick U, Jung N.
Bone Marrow Transplant . 2021 Mar;56(3):716-719. doi: 10.1038/s41409-020-01059-y. Epub 2020 Sep 18.
Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.
Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Cell Host Microbe . 2021 Jun 9;29(6):917-929.e4. doi: 10.1016/j.chom.2021.04.015. Epub 2021 May 3.
Analysis of Human Gut Microbiota Composition Associated to the Presence of Commensal and Pathogen Microorganisms in Côte d’Ivoire.
Veronica Di Cristanziano; Fedja Farowski; Federica Berrilli; Maristella Santoro; David Di Cave; Christophe Glé; Martin Daeumer; Alexander Thielen; Maike Wirtz; Rolf Kaiser; Kirsten Alexandra Eberhardt; Maria J. G. T. Vehreschild; Rossella D’Alfonso.
Microorganisms . 2021 Aug 18;9(8):1763. doi: 10.3390/microorganisms9081763.
Comparison of Two Real-time PCR Assays Targeting Ribosomal Sequences for the Identification of Cystoisospora belli in Human Stool Samples.
Martin Blohm; Andreas Hahn; Ralf Matthias Hagen; Kirsten Alexandra Eberhardt; Holger Rohde; Gérard Leboulle; Torsten Feldt; Fred Stephen Sarfo; Veronica Di Cristanziano; Hagen Frickmann; Ulrike Loderstädt.
Pathogens . 2021 Aug 19;10(8):1053. doi: 10.3390/pathogens10081053.
Intestinal colonization with Tropheryma whipplei – Clinical and immunological implications for HIV positive adults in Ghana.
Kirsten Alexandra Eberhardt; Fred Stephen Sarfo; Eva-Maria Klupp; Albert Dompreh; Veronica Di Cristanziano; Edmund Osei Kuffour; Richard Boateng; Betty Norman; Richard Odame Phillips; Martin Aepfelbacher; Torsten Feldt.
Microorganisms . 2021 Aug 22;9(8):1781. doi: 10.3390/microorganisms9081781.
Polymicrobial enteric infections in African infants with diarrhoea-results from a longitudinal prospective case-control study.
Melina Heinemann, Cornelia Strauchs, Marc Lütgehetmann, Martin Aepfelbacher, Eva-Maria Klupp, Ellis Owusu-Dabo, Thierry Rolling, Jakob P Cramer, Christof D Vinnemeier.
Clin Microbiol Infect . 2021 Apr 1;S1198-743X(21)00155-5. doi: 10.1016/j.cmi.2021.03.020.
Reisevorbereitungen für Patienten mit Psoriasis unter Immunsuppression.
Brigitte Stephan, Jörg Tittelbach, Silja Bühler.
J Dtsch Dermatol Ges . 2021 Feb;19(2):197-208. doi: 10.1111/ddg.14377_g.
TOURIST2 - Tracking of urgent risks in swiss travellers to the 6 main travel destinations - Feasibility and ethical considerations of a smartphone application-based study.
Vasiliki Baroutsou , Christoph Hatz, Ulf Blanke, Sarah R Haile, Jan Fehr, Andreas Neumayr, Milo A Puhan , Silja Bühler.
Travel Med Infect Dis . Jan-Feb 2021;39:101912. doi: 10.1016/j.tmaid.2020.101912. Epub 2020 Nov 7.
Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.
Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M, CANTAM study group.
PLoS Med . 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669. eCollection 2021 Jun.
Impact of dose, duration and immune status on efficacy of ultrashort telacebec regimens in mouse models of Buruli ulcer.
Oliver Komm, Deepak V. Almeida, Paul J. Converse, Till F. Omansen, Eric L. Nuermberger.
Antimicrob Agents Chemother . 2021 Oct 18;65(11):e0141821. doi: 10.1128/AAC.01418-21. Epub 2021 Aug 30.
Recurrent Swelling and Microfilaremia Caused by Dirofilaria repens Infection after Travel to India.
Huebl L, Tappe D, Giese M, Mempel S, Tannich E, Kreuels B, Ramharter M, Veletzky L, Jochum J.
Emerg Infect Dis . 2021 Jun;27(6):1701-1704. doi: 10.3201/eid2706.210592.
Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19.
Malsy J and Veletzky L, et al.
Clin Infect Dis . 2020 Oct 26;ciaa1637. doi: 10.1093/cid/ciaa1637. Online ahead of print.
Negative SARS-CoV-2 PCR or rapid antigen test result and the subsequent risk of being infectious: a mathematical simulation study.
Krumkamp R, Kreuels B, Jaeger VK, May J, Mikolajczyk R, Karch A.
BMC Med Res Methodol . 2021 Aug 10;21(1):165. doi: 10.1186/s12874-021-01361-3.
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients.
Velavan TP, Kuk S, Linh LTK, Lamsfus Calle C, Lalremruata A, Pallerla SR, Kreidenweiss A, Held J, Esen M, Gabor J, Neurohr EM, Shamsrizi P, Fathi A, Biecker E, Berg CP, Ramharter M, Addo MM, Kreuels B, Kremsner PG.
Sci Rep . 2021 Jul 14;11(1):14471. doi: 10.1038/s41598-021-93950-x.
Risk factors for and management of metronidazole-refractory giardiasis in international travellers: A retrospective analysis.
Peters TE, Kreuels B, Addo MM, Tannich E, Rothe C.
Travel Med Infect Dis . Sep-Oct 2021;43:102090. doi: 10.1016/j.tmaid.2021.102090. Epub 2021 Jun 1.
Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020.
Brehm TT, Heyer A, Roedl K, Jarczak D, Nierhaus A, Nentwich MF, van der Meirschen M, Schultze A, Christner M, Fiedler W, Kröger N, Huber TB, Klose H, Sterneck M, Jordan S, Kreuels B, Schmiedel S, Addo MM, Huber S, Lohse AW, Kluge S, Schulze Zur Wiesch J.
J Clin Med . 2021 May 24;10(11):2274. doi: 10.3390/jcm10112274.
Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi.
Stockdale AJ, Silungwe NM, Shawa IT, Kreuels B, Gordon MA, Geretti AM.
BMC Infect Dis . 2021 May 27;21(1):487. doi: 10.1186/s12879-021-06134-3.
Common virulence gene expression in adult first-time infected malaria patients and severe cases.
Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JA, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, Otto TD, Lavstsen T, Gilberger TW, Duffy MF, Bachmann A.
Elife . 2021 Apr 28;10:e69040. doi: 10.7554/eLife.69040.
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.
Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shahzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG.
Nat Commun . 2021 May 14;12(1):3001. doi: 10.1038/s41467-021-23559-1.
A call to caution when hydroxychloroquine is given to elderly patients with COVID-19.
Gabor JJ, Kreidenweiss A, Weber S, Salama M, Sulyok M, Sulyok Z, Koehne E, Esen M, Kreuels B, Shamsrizi P, Biecker E, Mordmüller B, Berg CP, Fusco S, Köhler C, Kubicka S, Leitlein J, Addo M, Ramharter M, Schwab M, Bissinger AL, Velavan TP, Krishna S, Kremsner PG.
Int J Infect Dis . 2021 May;106:265-268. doi: 10.1016/j.ijid.2021.04.009. Epub 2021 Apr 10.
Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR.
Olearo F, Nörz D, Heinrich F, Sutter JP, Roedl K, Schultze A, Wiesch JSZ, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, Lütgehetmann M.
J Clin Virol . 2021 Apr;137:104782. doi: 10.1016/j.jcv.2021.104782. Epub 2021 Mar 3.
Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project).
González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C.
BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197. PMID: 34815285.
Drug-induced hypersensitivity to artemisinin-based therapies for malaria.
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol. 2021 Sep 21:S1471-4922(21)00224-5. doi: 10.1016/j.pt.2021.08.011. Epub ahead of print. PMID: 34561157.
Comparison of Three Real-Time PCR Assays Targeting the SSU rRNA Gene, the COWP Gene and the DnaJ-Like Protein Gene for the Diagnosis of Cryptosporidium spp. in Stool Samples.
Weinreich F, Hahn A, Eberhardt KA, Feldt T, Sarfo FS, Di Cristanziano V, Frickmann H, Loderstädt U.
Pathogens. 2021 Sep 2;10(9):1131. doi: 10.3390/pathogens10091131. PMID: 34578163
Late presentation of hepatocellular carcinoma highlights the need for a public health programme to eliminate hepatitis B.
Nhlane R, Kreuels B, Mallewa J, Chetcuti K, Gordon MA, Stockdale AJ.
Lancet. 2021 Dec 18;398(10318):2288. doi: 10.1016/S0140-6736(21)02138-3. PMID: 34922670.
Attitudes, practices, and obstacles towards influenza vaccination for international travelers among travel health advisors in Germany: A questionnaire-based survey.
Brehm TT, Jordan S, Addo MM, Ramharter M, Kreuels B.
Travel Med Infect Dis. 2021 Dec 7:102233. doi: 10.1016/j.tmaid.2021.102233. Epub ahead of print. PMID: 34890809.
Hepatitis B vaccination impact and the unmet need for antiviral treatment in Blantyre, Malawi.
Stockdale AJ, Meiring JE, Shawa IT, Thindwa D, Silungwe NM, Mbewe M, Kachala R, Kreuels B, Patel P, Patel P, Henrion MYR, Bar-Zeev N, Swarthout TD, Heyderman RS, Gordon SB, Geretti AM, Gordon MA.
J Infect Dis. 2021 Nov 9:jiab562. doi: 10.1093/infdis/jiab562. Epub ahead of print. PMID: 34752631.
Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020
Brehm, T. T., Heyer, A., Roedl, K., Jarczak, D., Nierhaus, A., Nentwich, M. F., van der Meirschen, M., Schultze, A., Christner, M., Fiedler, W., Kröger, N., Huber, T. B., Klose, H., Sterneck, M., Jordan, S., Kreuels, B., Schmiedel, S., Addo, M. M., Huber, S., Lohse, A. W.
J Clin Med . 2021 May 24;10(11):2274. doi: 10.3390/jcm10112274.
Clinical presentation and disease course of 37 consecutive cases of progressive multifocal leukoencephalopathy (PML) at a German tertiary-care hospital: a retrospective observational study
Graf, L. M., Rosenkranz, S. C., Hölzemer, A., Hagel, C., Goebell, E., Jordan, S., Friese, M., Addo, M. M., Schulze zur Wiesch, J. & Beisel, C.
Front Neurol . 2021 Feb 4;12:632535. doi: 10.3389/fneur.2021.632535. eCollection 2021.
Diagnostic point-of-care ultrasound in medical inpatients at Queen Elizabeth Central Hospital, Malawi: an observational study of practice and evaluation of implementation
Limani, F., Dula, D., Keeley, A. J., Joekes, E., Phiri, T., Tembo, E., Gadama, L., Nnensa, V., Jordan, S., Mallewa, J. & Kreuels, B.
Trans R Soc Trop Med Hyg . 2021 Aug 2;115(8):863-869.
Rapid diagnostic test negative Plasmodium falciparum malaria in a traveller returning from Ethiopia.
Schlabe S, Reiter-Owona I, Nordmann T, Dolscheid-Pommerich R, Tannich E, Hoerauf A, Rockstroh J.
Malar J . 2021 Mar 12;20(1):145. doi: 10.1186/s12936-021-03678-2.
Clinical and microbiological characterization of sepsis and evaluation of sepsis scores.
Fuchs A, Tufa TB, Hörner J, Hurissa Z, Nordmann T, Bosselmann M, Abdissa S, Sorsa A, Orth HM, Jensen BO, MacKenzie C, Pfeffer K, Kaasch AJ, Bode JG, Häussinger D, Feldt T.
PLoS One . 2021 Mar 4;16(3):e0247646. doi: 10.1371/journal.pone.0247646. eCollection 2021.
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M.
Eur J Immunol . 2021 Nov 9. doi: 10.1002/eji.202149424. Online ahead of print.
An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany
Schmidberger J, Baumann S, Kratzer W, Schlingeloff P, Lachmann R, Stark K, Peters L, Gruener B, Ramharter M, Hoepffner PJ, Strohäker J, Blum A, Müllhaupt B, Lagler H.
Gesundheitswesen. 2021 Nov;83(11):e51-e56. doi: 10.1055/a-1138-0692. Epub 2020 Jun 8. PMID: 32512599
The four weeks before lockdown during the COVID-19 pandemic in Germany: a weekly serial cross-sectional survey on risk perceptions, knowledge, public trust and behaviour, 3 to 25 March 2020.
Betsch C, Korn L, Burgard T, Gaissmaier W, Felgendreff L, Eitze S, Sprengholz P, Böhm R, Stollorz V, Ramharter M, Promies N, De Bock F, Schmid P, Renner B, Wieler LH, Bosnjak M.
Euro Surveill . 2021 Oct;26(42):2001900. doi: 10.2807/1560-7917.ES.2021.26.42.2001900.
The Supposedly Innocuous Eye Worm: Or, What Could Make You Put Chili in Your Eye?
Veletzky L, Mombo-Ngoma G, Ramharter M.
Am J Trop Med Hyg . 2021 Sep 13;105(6):1448-1449. doi: 10.4269/ajtmh.21-0319.
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Deutsche COVID-19 OMICS Initiative (DeCOI); Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann.
Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. Epub 2021 Sep 4.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
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Nature . 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. Epub 2021 Oct 25.
Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers.
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Lancet Respir Med . 2021 Nov;9(11):e104-e105. doi: 10.1016/S2213-2600(21)00456-2. Epub 2021 Oct 20.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
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Cell . 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27.
Burden of disease in Gabon caused by loiasis: a cross-sectional survey
Veletzky L, Hergeth J, Stelzl D, Mischlinger J, Manego Zoleko R, Mombo-Ngoma G, McCall M, Adegnika A, Agnandji S, Metzger W, Matsiegui P, Lagler H, Mordmüller B. Budke C, Ramharter M.
The Lancet Infectious Diseases. 2020 Jun 22;https://doi.org/10.1016/S1473-3099(20)30256-5
Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana
Di Cristanziano V, Weimer K, Böttcher S, Sarfo FS, Dompreh A, Cesar LG, Knops E, Heger E, Wirtz M, Kaiser R, Norman B, Phillips RO, Feldt T, Eberhardt KA.
Viruses. 2020 Feb 16;12(2). pii: E221. doi: 10.3390/v12020221. PMID: 32079128
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data.
Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q, Baudin E, D'Alessandro U, Djimde AA, Dorsey G, Espié E, Fofana B, González R, Juma E, Karema C, Lasry E, Lell B, Lima N, Menéndez C, Mombo-Ngoma G, Moreira C, Nikiema F, Ouédraogo JB, Staedke SG, Tinto H, Valea I, Yeka A, Ghani AC, Guerin PJ, Okell LC.
BMC Med. 2020 Feb 25;18(1):47. PMID: 32098634 PMCID: PMC7043031 DOI: 10.1186/s12916-020-1494-3
Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
Erameh C, Edeawe O, Akhideno P, Eifediyi G, Omansen TF, Wagner C, Sarpong F, Koch T, Wicha S, Kurth F, Duraffour S, Oestereich L, Pahlmann M, Okogbenin S, Ogbaini-Emovon E, Günther S, Ramharter M, Groger M.
BMJ Open. 2020 Apr 16;10(4):e036936. doi: 10.1136/bmjopen-2020-036936.
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R.
Nat Biotechnol. 2020 Jun 26;. doi: 10.1038/s41587-020-0602-4. [Epub ahead of print] PubMed PMID: 32591762.
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M.
Cell Syst. 2020 Jun 2;. doi: 10.1016/j.cels.2020.05.012. [Epub ahead of print] PubMed PMID: 32619549; PubMed Central PMCID: PMC7264033.
Outpatient treatment of imported uncomplicated Plasmodium falciparum malaria: results from a survey among TropNet and GeoSentinel experts for tropical medicine.
Lingscheid T, Kurth F, Stegemann MS, Clerinx J, Calleri G, Rothe C, Angheben A, Gobbi F, Bisoffi Z, Hamer DH, Libman M, Hatz C, Zoller T.
J Travel Med. 2020 May 22;. doi: 10.1093/jtm/taaa082. [Epub ahead of print] PubMed PMID: 32442249.
Imported Malaria in Countries where Malaria Is Not Endemic: a Comparison of Semi-immune and Nonimmune Travelers.
Mischlinger J, Rönnberg C, Álvarez-Martínez MJ, Bühler S, Paul M,
Schlagenhauf P, Petersen E, Ramharter M.
Clin Microbiol Rev. 2020 Mar 11;33(2):e00104-19. doi: 10.1128/CMR.00104-19. PMID: 32161068; PMCID: PMC7067581.
Measles, Vaccines, and Types of Perception Bias in Public Debates.
Mischlinger J, Muranaka R, Bühler S, Ramharter M.
Clin Infect Dis. 2020 Mar 3;70(6):1258-1259. doi: 10.1093/cid/ciz586. PMID: 31298689.
Nerve decompression according to A.L. Dellon in Morton's neuroma - A retrospective analysis.
Mischitz M, Zeitlinger S, Mischlinger J, Rab M.
J Plast Reconstr Aesthet Surg. 2020 Jun;73(6):1099-1104. doi: 10.1016/j.bjps.2020.01.008. Epub 2020 Jan 22. PMID: 32171681.
Vaccination in Patients with Inflammatory Bowel Diseases.
Manser CN, Maillard MH, Rogler G, Schreiner P, Rieder F, Bühler S.
Digestion. 2020 Jan 22:1-11. doi: 10.1159/000503253. Epub ahead of print. PMID: 31968344.
Rabies exposure in travellers to Asia, the Middle East, Africa, South and Central America-a German Airport study.
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J Travel Med. 2020 Apr 18:taaa058. doi: 10.1093/jtm/taaa058. Epub ahead of print. PMID: 32307548.
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
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Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle.
Göschl L, Winkler S, Dmytrus J, Heredia RJ, Lagler H, Ramharter M, Scheinecker C, Bonelli M, Schmetterer K, Pickl WF, Grabmeier-Pfistershammer K, Hershfield MS, Boztug K, Förster-Waldl E, Gualdoni GA.
J Clin Immunol. 2020 Jan;40(1):223-226. doi: 10.1007/s10875-019-00700-w. Epub 2019 Nov 4. PMID: 31686313
Integrated safety analysis: Frequency of urinary tract infections in patients with psoriasis treated with ixekizumab.
Smith SD, Conrad C, Ramharter M, Gottlieb AB, Patel H, Xu W, Riedl E, Schuster C.
J Am Acad Dermatol. 2020 Jul;83(1):261-263. doi: 10.1016/j.jaad.2020.02.045. Epub 2020 Feb 21. PMID: 32092375
Diagnostic Techniques of Soil-Transmitted Helminths: Impact on Control Measures.
Mbong Ngwese M, Prince Manouana G, Nguema Moure PA, Ramharter M, Esen M, Adégnika AA.
Trop Med Infect Dis. 2020 Jun 5;5(2):93. doi: 10.3390/tropicalmed5020093. PMID: 32516900
Evaluating case definitions for Ebola virus disease.
Ramharter M, Günther S.
Lancet Infect Dis. 2020 Jun 25:S1473-3099(20)30272-3. doi: 10.1016/S1473-3099(20)30272-3. Online ahead of print. PMID: 32593319
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Harrison N, Grabmeier-Pfistershammer K, Graf A, Schwarzinger I, Aberle JH, Stiasny K, Greinix H, Rabitsch W, Kalhs P, Ramharter M, Burgmann H, Forstner C.
NPJ Vaccines. 2020 Jul 24;5:67. doi: 10.1038/s41541-020-00215-1. eCollection 2020. PMID: 32728481
Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings.
Remppis J, Verheyden A, Bustinduy AL, Heller T, García-Tardón N, Manouana GP, Obiang R, Adegnika AA, Grobusch MP, Ramharter M, Joekes E, Bélard S.
Trans R Soc Trop Med Hyg. 2020 Jan 6;114(1):38-48. doi: 10.1093/trstmh/trz101. PMID: 31735956
An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany
Schmidberger J, Baumann S, Kratzer W, Schlingeloff P, Lachmann R, Stark K, Peters L, Gruener B, Ramharter M, Hoepffner PJ, Strohäker J, Blum A, Müllhaupt B, Lagler H.
Gesundheitswesen. 2020 Jun 8. doi: 10.1055/a-1138-0692. Online ahead of print. PMID: 32512599
A case for adoption of continuous albendazole treatment regimen for human echinococcal infections.
Tamarozzi F, Horton J, Muhtarov M, Ramharter M, Siles-Lucas M, Gruener B, Vuitton DA, Bresson-Hadni S, Manciulli T, Brunetti E.
PLoS Negl Trop Dis. 2020 Sep 17;14(9):e0008566. doi: 10.1371/journal.pntd.0008566. eCollection 2020 Sep. PMID: 32941434
Traveling into the abyss: risk perception of German travelers at the onset of the COVID-19 pandemic.
Shamsrizi P, Jochum J, Kreuels B, Ramharter M.
Am J Trop Med Hyg. 2020 Aug 18
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Schmid N, Ciurea A, Gabay C, Hasler P, Fehr J, Müller R, Villiger P, Walker U, Hatz C, Bühler S.
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Safety and immunogenicity of a primary yellow fever vaccination under low-dose methotrexate therapy-a prospective multi-centre pilot study1.
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Risk estimation for air travel-induced malaria transmission in central Europe - A mathematical modelling study.
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Travel Med Infect Dis. 2020 Jul-Aug;36:101564. doi: 10.1016/j.tmaid.2020.101564. Epub 2020 Jan 28.PMID: 32004733
The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM.
J Hepatol. 2020 Sep;73(3):523-532. doi: 10.1016/j.jhep.2020.04.008. Epub 2020 Apr 23.
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Detection of SARS-CoV-2 viremia before onset of COVID-19 symptoms in an allo-transplanted patient with acute leukemia.
Veronica Di Cristanziano, Charlotte Meyer-Schwickerath, Kirsten Alexandra Eberhardt, Jan Rybniker, Eva Heger, Elena Knops, Michael Hallek, Florian Klein, Udo Holtick, and Norma Jung
Bone Marrow Transplantation, Accepted for publication on September 2nd 2020 IF 4,7
A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon.
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The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound
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Am J Trop Med Hyg. 2020;103(1):325-333. doi:10.4269/ajtmh.19-0835
Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections.
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Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy.
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J Infect Dis. 2020;221(2):293-303. doi:10.1093/infdis/jiz451
Case Report: Acute Vision Loss in a Young Returning Traveler with Dengue Fever.
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Am J Trop Med Hyg. 2020 Sep 8. doi: 10.4269/ajtmh.20-0562. Online ahead of print. PMID: 32901600
Treatment and re-treatment results of HCV patients in the DAA era.
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Relapsing cutaneous leishmaniasis in a patient requiring TNF-α-inhibitor Infliximab for Takayasu-arteritis: Case report and review of the literature
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Risk factors for different intestinal pathogens among patients with traveler's diarrhea: A retrospective analysis at a German travel clinic (2009-2017).
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RNAemia Corresponds to Disease Severity and Antibody Response in Hospitalized COVID-19 Patients.
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Hookworm infection in returning travellers and migrants: a 10-year case series at a German center for tropical medicine.
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Rational antimicrobial therapy - recommendations for common infections
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Dtsch Med Wochenschr. 2020 Nov;145(23):1673-1682. doi: 10.1055/a-1114-3946
Describing nearly two decades of Chagas disease in Germany and the lessons learned: a retrospective study on screening, detection, diagnosis, and treatment of Trypanosoma cruzi infection from 2000 - 2018.
Guggenbühl Noller JM, Froeschl G, Eisermann P, Jochum J, Theuring S, Reiter-Owona I, Bissinger AL, Hoelscher M, Bakuli A, von Sonnenburg FF, Rothe C, Bretzel G, Albajar-Viñas P, Grout L, Pritsch M.
BMC Infect Dis. 2020 Dec 3;20(1):919. doi: 10.1186/s12879-020-05600-8.
Diagnostic point-of-care ultrasound in medical inpatients at Queen Elizabeth Central Hospital, Malawi: an observational study of practice and evaluation of implementation.
Limani F, Dula D, Keeley AJ, Joekes E, Phiri T, Tembo E, Gadama L, Nnensa V, Jordan S, Mallewa J, Kreuels B.
Trans R Soc Trop Med Hyg. 2020 Nov 16:traa137. doi: 10.1093/trstmh/traa137. Online ahead of print. PMID: 33197258
A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana.
Winter D, Akenten CW, Eibach D, Fickenscher H, Eis-Hübinger A, May J, Kreuels B.
Sci Rep. 2020 Sep 24;10(1):15695. doi: 10.1038/s41598-020-72657-5. PMID: 32973247
Paediatric formulations of artemisinin-based combination therapies for treating uncomplicated malaria in children.
Bélard S, Ramharter M, Kurth F.
Cochrane Database Syst Rev. 2020 Dec 8;12:CD009568. doi: 10.1002/14651858.CD009568.pub2. PMID: 33289099 Review.
Molecular epidemiology of Mansonella species in Gabon.
Sandri TL, Kreidenweiss A, Cavallo S, Weber D, Juhas S, Rodi M, Woldearegai TG, Gmeiner M, Veletzky L, Ramharter M, Tazemda-Kuitsouc GB, Matsiegui PB, Mordmüller B, Held J.
J Infect Dis. 2020 Oct 25:jiaa670. doi: 10.1093/infdis/jiaa670. Online ahead of print. PMID: 33099649
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Clin Infect Dis. 2020 Oct 26 : ciaa1637. Published online 2020 Oct 26. doi: 10.1093/cid/ciaa1637 PMCID: PMC7665388
A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting
Sarah M Hicks, Kai Pohl, Teresa Neeman, Hayley A McNamara, Kate M Parsons, Jin-shu He, Sidra A Ali, Samina Nazir, Louise C Rowntree, Thi H O Nguyen, Katherine Kedzierska, Denise L Doolan, Carola G Vinuesa, Matthew C Cook, Nicholas Coatsworth, Paul S Myles, Florian Kurth, Leif E Sander, Graham J Mann, Russell L Gruen, Amee J George, Elizabeth E Gardiner, Ian A Cockburn, SARS-CoV-2 Testing in Elective Surgery Collaborators
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A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model
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Am J Trop Med Hyg. 2020 Aug 18
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Epid Bull 2020; 46:3–10 | DOI 10.25646/7208
Drittlinientherapie mit Quinacrin und Metronidazol bei refraktärer Giardiasis
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Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a Hightransmission Setting
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Flucelvax Tetra: a surface antigen, inactivated, influenza vaccine prepared in cell cultures.
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FDG-PET/MRI imaging for the management of alveolar echinococcosis: initial clinical experience at a reference centre in Austria.
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Global Epidemiology of Buruli Ulcer, 2010-2017, and Analysis of 2014 WHO Programmatic Targets.
Omansen TF, Erbowor-Becksen A, Yotsu R, van der Werf TS, Tiendrebeogo A, Grout L, Asiedu K.
Emerg Infect Dis. 2019 Dec;25(12):2183-2190. doi: 10.3201/eid2512.190427.
In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model.
Omansen TF, Marcsisin RA, Chua BY, Zeng W, Jackson DC, Porter JL, Stienstra Y, van der Werf TS, Stinear TP.
Am J Trop Med Hyg. 2019 Dec;101(6):1312-1321. doi: 10.4269/ajtmh.18-0959.
Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial.
Adegbite BR, Edoa JR, Honkpehedji YJ, Zinsou FJ, Dejon-Agobe JC, Mbong-Ngwese M, Lotola-Mougueni F, Koehne E, Lalremruata A, Kreidenweiss A, Nguyen TT, Kun J, Agnandji ST, Lell B, Safiou AR, Obone Atome FA, Mombo-Ngoma G, Ramharter M, Velavan TP, Mordmüller B, Kremsner PG, Adegnika AA.
Malar J. 2019 Dec 16;18(1):424. doi: 10.1186/s12936-019-3015-4.
Determinants of post-malarial anemia in African children treated with parenteral artesunate.
Scheu K, Adegnika AA, Addo MM, Ansong D, Cramer JP, Fürst S, Kremsner PG, Kurth F, Jacobs T, May J, Ramharter M, Sylverken J, Vinnemeier CD, Agbenyega T, Rolling T.
Sci Rep. 2019 Dec 2;9(1):18134. doi: 10.1038/s41598-019-54639-4.
Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings.
Remppis J, Verheyden A, Bustinduy AL, Heller T, García-Tardón N, Manouana GP, Obiang R, Adegnika AA, Grobusch MP, Ramharter M, Joekes E, Bélard S.
Trans R Soc Trop Med Hyg. 2019 Nov 16. pii: trz101.
Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle.
Göschl L, Winkler S, Dmytrus J, Heredia RJ, Lagler H, Ramharter M, Scheinecker C, Bonelli M, Schmetterer K, Pickl WF, Grabmeier-Pfistershammer K, Hershfield MS, Boztug K, Förster-Waldl E, Gualdoni GA.
J Clin Immunol. 2019 Nov 4.
Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy.
Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A.
J Infect Dis. 2019 Nov 2.
DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon.
Nguyen TT, Nzigou Mombo B, Lalremruata A, Koehne E, Zoleko Manego R, Dimessa Mbadinga LB, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Velavan TP, Ramharter M, Mordmüller B, Mombo-Ngoma G.
Malar J. 2019 Oct 2;18(1):336.
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.
Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, Mayor A.
Emerg Infect Dis. 2019 Oct;25(10):1851-1860.
Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis.
WorldWide Antimalarial Resistance Network Methodology Study Group.
Malar J. 2019 Jul 5;18(1):225. doi: 10.1186/s12936-019-2837-4.
Caseload and Case Fatality of Lassa Fever in Nigeria, 2001-2018: A Specialist Center's Experience and Its Implications.
Akpede GO, Asogun DA, Okogbenin SA, Dawodu SO, Momoh MO, Dongo AE, Ike C, Tobin E, Akpede N, Ogbaini-Emovon E, Adewale AE, Ochei O, Onyeke F, Okonofua MO, Atafo RO, Odia I, Adomeh DI, Odigie G, Ogbeifun C, Muebonam E, Ihekweazu C, Ramharter M, Colubri A, Sarbeti PC, Happi CT, Günther S, Agbonlahor DE.
Front Public Health. 2019 Jun 25;7:170. doi: 10.3389/fpubh.2019.00170.
[Cardiac manifestations of tropical diseases]
Kraef C, Ramharter M.
Herz. 2019 Feb;44(1):83-91.
Evaluation of direct costs associated with alveolar and cystic echinococcosis in Austria.
Lötsch F, Budke CM, Auer H, Kaczirek K, Waneck F, Lagler H, Ramharter M.
PLoS Negl Trop Dis. 2019 Jan 31;13(1):e0007110.
Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon.
Ramharter M, Schwab M, Mombo-Ngoma G, Zoleko Manego R, Akerey-Diop D, Basra A, Mackanga JR, Würbel H, Wojtyniak JG, Gonzalez R, Hofmann U, Geditz M, Matsiegui PB, Kremsner PG, Menendez C, Kerb R, Lehr T.
Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01113-18.
African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, Ndong Ngomo JM, Varo R, Dossou Y, Tshefu AK, Duong TT, Phuc BQ, Laurijssens B, Klopper R, Khim N, Legrand E, Ménard D.
Malar J. 2019 Apr 10;18(1):126. doi: 10.1186/s12936-019-2756-4.
Immediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study).
Schäfer G, Hoffmann C, Arasteh K, Schürmann D, Stephan C, Jensen B, Stoll M, Bogner JR, Faetkenheuer G, Rockstroh J, Klinker H, Härter G, Stöhr A, Degen O, Freiwald E, Hüfner A, Jordan S, Schulze Zur Wiesch J, Addo M, Lohse AW, van Lunzen J, Schmiedel S;
AIDS Res Ther. 2019 Nov 15;16(1):34. doi: 10.1186/s12981-019-0250-2.
Schistosomiasis detected during appendectomy.
Kraef C, Arand J, Veletzky L, Schäfer H, Jordan S, Schmiedel S, Ramharter M.
Lancet. 2018 Jun 23;391(10139):2546. doi: 10.1016/S0140-6736(18)31329-1. No abstract available. PMID: 29976471
Validity and reliability of methods to microscopically detect and quantify malaria parasitaemia.
Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Mombo-Ngoma G, Mordmüller B, Ramharter M.
Trop Med Int Health. 2018 Jun 28. doi: 10.1111/tmi.13124. [Epub ahead of print]
DSM265: a novel drug for single-dose cure of Plasmodium falciparum malaria.
Bélard S, Ramharter M.
Lancet Infect Dis. 2018 Jun 13. pii: S1473-3099(18)30374-8. doi: 10.1016/S1473-3099(18)30374-8. [Epub ahead of print]
Use of Capillary Blood Samples Leads to Higher Parasitemia Estimates and Higher Diagnostic Sensitivity of Microscopic and Molecular Diagnostics of Malaria than Venous Blood Samples.
Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Tannich E, Mombo-Ngoma G, Mordmüller B, Ramharter M.
J Infect Dis. 2018 May 25. doi: 10.1093/infdis/jiy319. [Epub ahead of print]
Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts.
Lötsch F, Mombo-Ngoma G, Mischlinger J, Groger M, Veletzky L, Adegnika AA, Lell B, Agnandji ST, Bouyou-Akotet M, Obermüller M, Wassermann M, Schneider R, Auer H, Ramharter M.
Am J Trop Med Hyg. 2018 Jul;99(1):97-101. doi: 10.4269/ajtmh.17-0955. Epub 2018 May 17.
Dalbavancin as primary and sequential treatment for Gram-positive infective endocarditis: 2-Year Experience at the General Hospital of Vienna.
Tobudic S, Forstner C, Burgmann H, Lagler H, Ramharter M, Steininger C, Vossen MG, Winkler S, Thalhammer F.
Clin Infect Dis. 2018 Apr 5. doi: 10.1093/cid/ciy279. [Epub ahead of print]
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.
Hede MS, Fjelstrup S, Lötsch F, Zoleko RM, Klicpera A, Groger M, Mischlinger J, Endame L, Veletzky L, Neher R, Simonsen AKW, Petersen E, Mombo-Ngoma G, Stougaard M, Ho YP, Labouriau R, Ramharter M, Knudsen BR.
Sci Rep. 2018 Mar 7;8(1):4122. doi: 10.1038/s41598-018-22378-7.
Behavioural and clinical predictors for Loiasis.
Mischlinger J, Veletzky L, Tazemda-Kuitsouc GB, Pitzinger P, Matsegui PB, Gmeiner M, Lagler H, Gebru T, Held J, Mordmüller B, Ramharter M.
J Glob Health. 2018 Jun;8(1):010413. doi: 10.7189/jogh.08.010413.
Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection.
Veletzky L, Groger M, Lagler H, Walochnik J, Auer H, Fuehrer HP, Ramharter M.
Malar J. 2018 Feb 9;17(1):78. doi: 10.1186/s12936-018-2226-4.
Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon.
Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Zoleko-Manego R, Endamne L, Klicpera A, Kim J, Nguyen T, Flohr L, Remppis J, Matsiegui PB, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Ramharter M.
Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01758-17. doi: 10.1128/AAC.01758-17. Print 2018 Mar.
Leishmaniasis in Northern Syria during the Civil War
Rehmann K, Walochnik J, Mischlinger J, Alassil B, Allan R, Ramharter M.
Emerging Infectious Diseases 2018 Nov;24(11):1973-1981. doi: 10.3201/eid2411.172146.
Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Primary and Secondary Prophylaxis of Variceal Bleeding in Hepatic Schistosomiasis: A Case Series
Kraef C, Arand J, Jordan S, Galaski J, Kluwe J, Lohse A, Addo M, Ramharter M, Schmiedel S.
Travel Med Infect Dis. 2019 Jan 11. pii: S1477-8939(18)30237-0. doi: 10.1016/j.tmaid.2019.01.006.
Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors.
Kraef C, Schlein C, Hiller J, Westhölter D, Denzer U, Horvatits T, Peine S, Lohse AW, Luetgehetman M, Polywka S, Pischke S.
J Clin Virol. 2018 Aug;105:26-30. doi: 10.1016/j.jcv.2018.05.013. Epub 2018 May 29.
Specific cholecystitis: An unusual presentation of extrapulmonary tuberculosis.
Veletzky L, Österreicher ZA, Mayer KA, Ba-Ssalamah A, Ramharter M, Winkler S.
Int J Infect Dis. 2018 Dec;77:16-17. doi: 10.1016/j.ijid.2018.09.010. Epub 2018 Sep 20.
Dalbavancin for treatment of implant-related methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model.
Kussmann M, Obermueller M, Berndl F, Reischer V, Veletzky L, Burgmann H, Poeppl W.
Sci Rep. 2018 Jun 25;8(1):9661. doi: 10.1038/s41598-018-28006-8. PMID: 29941909
Concordance of three alternative gestational age assessments for pregnant women from four African countries: A secondary analysis of the MIPPAD trial.
Rada S, Gamper J, González R, Mombo-Ngoma G, Ouédraogo S, Kakolwa MA, Zoleko-Manego R, Sevene E, Kabanywanyi AM, Accrombessi M, Briand V, Cot M, Vala A, Kremsner PG, Abdulla S, Massougbodgi A, Nhacolo A, Aponte JJ, Macete E, Menéndez C, Ramharter M.
PLoS One. 2018 Aug 6;13(8):e0199243. doi: 10.1371/journal.pone.0199243. eCollection 2018.
Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon.
Dejon-Agobé JC, Zinsou JF, Honkpehedji YJ, Ateba-Ngoa U, Edoa JR, Adegbite BR, Mombo-Ngoma G, Agnandji ST, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA.
PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663. doi: 10.1371/journal.pntd.0006663. eCollection 2018 Aug.
Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.
Salzer HJF, Stoney RJ, Angelo KM, Rolling T, Grobusch MP, Libman M, López-Vélez R, Duvignaud A, Ásgeirsson H, Crespillo-Andújar C, Schwartz E, Gautret P, Bottieau E, Jordan S, Lange C, Hamer DH; GeoSentinel Surveillance Network.
J Travel Med. 2018 Aug 1;25(1). doi: 10.1093/jtm/tay055.
Retrospective clinical case series study in 2017 identifies Plasmodium knowlesi as most frequent Plasmodium species in returning travellers from Thailand to Germany.
Froeschl G, Nothdurft HD, von Sonnenburg F, Bretzel G, Polanetz R, Kroidl I, Seilmaier M, Orth HM, Jordan S, Kremsner P, Vygen-Bonnet S, Pritsch M, Hoelscher M, Rothe C.
Euro Surveill. 2018 Jul;23(29). doi: 10.2807/1560-7917.ES.2018.23.29.1700619.
Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa, Pakistan.
Rehman K, Bettani MAK, Veletzky L, Afridi S, Ramharter M.
Infect Dis Poverty. 2018 Nov 19;7(1):116. doi: 10.1186/s40249-018-0499-z. PMID: 30449274
Import of community-associated, methicillin-resistant Staphylococcus aureus to Europe through skin and soft tissue infection in intercontinental travellers, 2011-2016.
Nurjadi D, Fleck R, Lindner A, Schäfer J, Gertler M, Mueller A, Lagler H, Van Genderen PJ, Caumes E, Boutin S, Kuenzli E, Gascon J, Kantele A, Grobusch MP, Heeg K, Zanger P; StaphTrav Network.
Clin Microbiol Infect. 2018 Oct 10. pii: S1198-743X(18)30663-3. doi: 10.1016/j.cmi.2018.09.023. [Epub ahead of print] PMID: 30315958 [PubMed - as supplied by publisher]
Dalbavancin for treatment of implant-related methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model.
Kussmann M, Obermueller M, Berndl F, Reischer V, Veletzky L, Burgmann H, Poeppl W.
Sci Rep. 2018 Jun 25;8(1):9661. doi: 10.1038/s41598-018-28006-8. PMID: 29941909
Concordance of three alternative gestational age assessments for pregnant women from four African countries: A secondary analysis of the MIPPAD trial.
Rada S, Gamper J, González R, Mombo-Ngoma G, Ouédraogo S, Kakolwa MA, Zoleko-Manego R, Sevene E, Kabanywanyi AM, Accrombessi M, Briand V, Cot M, Vala A, Kremsner PG, Abdulla S, Massougbodgi A, Nhacolo A, Aponte JJ, Macete E, Menéndez C, Ramharter M.
PLoS One. 2018 Aug 6;13(8):e0199243. doi: 10.1371/journal.pone.0199243. eCollection 2018. PMID: 30080869
Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon.
Dejon-Agobé JC, Zinsou JF, Honkpehedji YJ, Ateba-Ngoa U, Edoa JR, Adegbite BR, Mombo-Ngoma G, Agnandji ST, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA.
PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663. doi: 10.1371/journal.pntd.0006663. eCollection 2018 Aug.
Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.
Salzer HJF, Stoney RJ, Angelo KM, Rolling T, Grobusch MP, Libman M, López-Vélez R, Duvignaud A, Ásgeirsson H, Crespillo-Andújar C, Schwartz E, Gautret P, Bottieau E, Jordan S, Lange C, Hamer DH; GeoSentinel Surveillance Network.
J Travel Med. 2018 Aug 1;25(1). doi: 10.1093/jtm/tay055.
Retrospective clinical case series study in 2017 identifies Plasmodium knowlesi as most frequent Plasmodium species in returning travellers from Thailand to Germany.
Froeschl G, Nothdurft HD, von Sonnenburg F, Bretzel G, Polanetz R, Kroidl I, Seilmaier M, Orth HM, Jordan S, Kremsner P, Vygen-Bonnet S, Pritsch M, Hoelscher M, Rothe C.
Euro Surveill. 2018 Jul;23(29). doi: 10.2807/1560-7917.ES.2018.23.29.1700619.
Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa, Pakistan.
Rehman K, Bettani MAK, Veletzky L, Afridi S, Ramharter M.
Infect Dis Poverty. 2018 Nov 19;7(1):116. doi: 10.1186/s40249-018-0499-z. PMID: 30449274
Import of community-associated, methicillin-resistant Staphylococcus aureus to Europe through skin and soft tissue infection in intercontinental travellers, 2011-2016.
Nurjadi D, Fleck R, Lindner A, Schäfer J, Gertler M, Mueller A, Lagler H, Van Genderen PJ, Caumes E, Boutin S, Kuenzli E, Gascon J, Kantele A, Grobusch MP, Heeg K, Zanger P;
Clin Microbiol Infect. 2018 Oct 10. pii: S1198-743X(18)30663-3. doi: 10.1016/j.cmi.2018.09.023. [Epub ahead of print] PMID: 30315958 [PubMed - as supplied by publisher]
Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon.
Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Joerg M, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG.
Clin Infect Dis. 2017 Dec 26. doi: 10.1093/cid/cix1122. [Epub ahead of print]
Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial.
Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG.
PLoS Med. 2017 Oct 6;14(10):e1002402. doi: 10.1371/journal.pmed.1002402. eCollection 2017 Oct.
Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing.
Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Bélard S, Mombo-Ngoma G, Ramharter M, Kremsner PG, Mordmüller B, Held J.
Malar J. 2017 Oct 3;16(1):398. doi: 10.1186/s12936-017-2044-0.
FDG-PET/MRI in alveolar echinococcosis.
Lötsch F, Waneck F, Auer H, Kaczirek K, Karanikas G, Ramharter M.
Int J Infect Dis. 2017 Nov;64:67-68. doi: 10.1016/j.ijid.2017.09.006. Epub 2017 Sep 19.
Dalbavancin for outpatient parenteral antimicrobial therapy of skin and soft tissue infections in a returning traveller : Proposal for novel treatment indications.
Mischlinger J, Lagler H, Harrison N, Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):642-645. doi: 10.1007/s00508-017-1243-6. Epub 2017 Aug 3.
Prof. Walther H. Wernsdorfer (1928-2016).
Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):650-651. doi: 10.1007/s00508-017-1236-5. Epub 2017 Jul 25.
Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.
Ndam NT, Mbuba E, González R, Cisteró P, Kariuki S, Sevene E, Rupérez M, Fonseca AM, Vala A, Maculuve S, Jiménez A, Quintó L, Ouma P, Ramharter M, Aponte JJ, Nhacolo A, Massougbodji A, Briand V, Kremsner PG, Mombo-Ngoma G, Desai M, Macete E, Cot M, Menéndez C, Mayor A.
BMC Med. 2017 Jul 17;15(1):130. doi: 10.1186/s12916-017-0893-6.
Direct detection of Anaplasma phagocytophilum by polymerase chain reaction followed by electrospray ionization mass spectrometry from human blood.
Lagler H, Harrison N, Kussmann M, Obermüller M, Burgmann H, Makristathis A, Ramharter M.
Int J Infect Dis. 2017 Jul;60:61-63. doi: 10.1016/j.ijid.2017.05.006. Epub 2017 May 16.
Severe malaria in Europe: an 8-year multi-centre observational study.
Kurth F, Develoux M, Mechain M, Malvy D, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Lingscheid T, Kern P, Kapaun A, da Cunha JS, Pongratz P, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T.
Malar J. 2017 Jan 31;16(1):57. doi: 10.1186/s12936-016-1673-z.
Progressive Perforation of the Nasal Septum Due to Leishmania major: A Case of Mucosal Leishmaniasis in a Traveler.
Harrison N, Walochnik J, Ramsebner R, Veletzky L, Lagler H, Ramharter M.
Am J Trop Med Hyg. 2017 Mar;96(3):653-655. doi: 10.4269/ajtmh.16-0809. Epub 2017 Apr 6.
Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon.
Manego RZ, Mombo-Ngoma G, Witte M, Held J, Gmeiner M, Gebru T, Tazemda B, Mischlinger J, Groger M, Lell B, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Ramharter M, Matsiegui PB.
BMC Public Health. 2017 Jan 28;17(1):130. doi: 10.1186/s12889-017-4045-x.
Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function.
Schuster C, Binder C, Strassl R, Aichelburg MC, Blackwell E, Pavo N, Ramharter M, Hülsmann M, Grabmeier-Pfistershammer K, Rieger A, Goliasch G.
AIDS. 2017 Jan 28;31(3):395-400. doi: 10.1097/QAD.0000000000001350.
Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon.
Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, Agobe JC, Lell B, Matsiegui PB, Gonzales R, Agnandji ST, Yazdanbakhsh M, Menendez C, Kremsner PG, Adegnika AA, Ramharter M.
Int J Parasitol. 2017 Jan;47(1):69-74. doi: 10.1016/j.ijpara.2016.11.001. Epub 2016 Dec 18.
Zika virus-induced itching rash in a returning traveller from Brazil.
Veletzky L, Knafl D, Schuster C, Aberle SW, Stiasny K, Ramharter M, Lagler H.
Int J Infect Dis. 2017 Jan;54:13-14. doi: 10.1016/j.ijid.2016.11.004. Epub 2016 Nov 7
Seroprevalence of Toxocara spp. in a rural population in Central African Gabon.
Lötsch F, Obermüller M, Mischlinger J, Mombo-Ngoma G, Groger M, Adegnika AA, Agnandji ST, Schneider R, Auer H, Ramharter M.
Parasitol Int. 2016 Dec;65(6 Pt A):632-634. doi: 10.1016/j.parint.2016.09.001. Epub 2016 Sep 2.
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania.
Harrison N, Burgmann H, Forstner C, Ramharter M, Széll M, Schötta AM, Stanek G, Markowicz M.
Wien Klin Wochenschr. 2016 Aug;128(15-16):602-5. doi: 10.1007/s00508-016-1047-0. Epub 2016 Aug 3.
Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study.
Mombo-Ngoma G, Mackanga JR, González R, Ouedraogo S, Kakolwa MA, Manego RZ, Basra A, Rupérez M, Cot M, Kabanywany AM, Matsiegui PB, Agnandji ST, Vala A, Massougbodji A, Abdulla S, Adegnika AA, Sevene E, Macete E, Yazdanbakhsh M, Kremsner PG, Aponte JJ, Menéndez C, Ramharter M.
BMJ Open. 2016 Jun 29;6(6):e011783. doi: 10.1136/bmjopen-2016-011783.
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
Single dose treatment of malaria - current status and perspectives.
Mischlinger J, Agnandji ST, Ramharter M.
Expert Rev Anti Infect Ther. 2016 Jul;14(7):669-78. doi: 10.1080/14787210.2016.1192462. Epub 2016 Jun 7.
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data.
WWARN Gametocyte Study Group.
BMC Med. 2016 May 24;14:79. doi: 10.1186/s12916-016-0621-7.
The first meeting of the European Register of Cystic Echinococcosis (ERCE).
Rossi P, Tamarozzi F, Galati F, Pozio E, Akhan O, Cretu CM, Vutova K, Siles-Lucas M, Brunetti E, Casulli A; HERACLES extended network.
Parasit Vectors. 2016 Apr 28;9:243. doi: 10.1186/s13071-016-1532-3.
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data.
Lötsch F, Naderer J, Skuhala T, Groger M, Auer H, Kaczirek K, Waneck F, Ramharter M.
Parasitol Res. 2016 Aug;115(8):2995-3001. doi: 10.1007/s00436-016-5054-x. Epub 2016 Apr 16.
Effect of mild medical hypothermia on in vitro growth of Plasmodium falciparum and the activity of anti-malarial drugs.
Rehman K, Sauerzopf U, Veletzky L, Lötsch F, Groger M, Ramharter M.
Malar J. 2016 Mar 15;15:162. doi: 10.1186/s12936-016-1215-8.
Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study.
Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, Kakolwa MA, Vala A, Accrombessi M, Briand V, Aponte JJ, Manego Zoleko R, Adegnika AA, Cot M, Kremsner PG, Massougbodji A, Abdulla S, Ramharter M, Macete E, Menéndez C.
PLoS Med. 2016 Feb 23;13(2):e1001964. doi: 10.1371/journal.pmed.1001964. eCollection 2016 Feb.
Anaplasmataceae-Specific PCR for Diagnosis and Therapeutic Guidance for Symptomatic Neoehrlichiosis in Immunocompetent Host.
Schwameis M, Auer J, Mitteregger D, Simonitsch-Klupp I, Ramharter M, Burgmann H, Lagler H.
Emerg Infect Dis. 2016 Feb;22(2):281-4. doi: 10.3201/eid2202.141762.
Alterations of blood coagulation in controlled human malaria infection.
Riedl J, Mordmüller B, Koder S, Pabinger I, Kremsner PG, Hoffman SL, Ramharter M, Ay C.
Malar J. 2016 Jan 7;15:15. doi: 10.1186/s12936-015-1079-3.
Imported malaria in pregnant women: A retrospective pooled analysis.
Käser AK, Arguin PM, Chiodini PL, Smith V, Delmont J, Jiménez BC, Färnert A, Kimura M, Ramharter M, Grobusch MP, Schlagenhauf P.
Travel Med Infect Dis. 2015 Jul-Aug;13(4):300-10. doi: 10.1016/j.tmaid.2015.06.011. Epub 2015 Jul 9.
Activity of antimicrobial drugs against bacterial pathogens under mild hypothermic conditions.
Wallmüller C, Herold B, Sterz F, Makristathis A, Ramharter M.
Am J Emerg Med. 2015 Oct;33(10):1445-8. doi: 10.1016/j.ajem.2015.07.005. Epub 2015 Jul 4.
Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns--A cross-sectional delivery survey in Central Gabon.
Capan-Melser M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Manego-Zoleko R, Würbel H, Lötsch F, Groger M, Skoll M, Schwing J, Schipulle U, Matsiegui PB, González R, Menendez C, Kremsner PG, Adegnika AA, Agnandji ST, Ramharter M.
Int J Infect Dis. 2015 Oct;39:16-9. doi: 10.1016/j.ijid.2015.08.004. Epub 2015 Aug 10.
Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study.
Kurth F, Develoux M, Mechain M, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Pongratz P, Kern P, Saraiva da Cunha J, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T; TropNet Severe Malaria Investigator Group.
Clin Infect Dis. 2015 Nov 1;61(9):1441-4. doi: 10.1093/cid/civ575. Epub 2015 Jul 17.
Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy.
Sicuri E, Fernandes S, Macete E, González R, Mombo-Ngoma G, Massougbodgi A, Abdulla S, Kuwawenaruwa A, Katana A, Desai M, Cot M, Ramharter M, Kremsner P, Slustker L, Aponte J, Hanson K, Menéndez C.
PLoS One. 2015 Apr 27;10(4):e0125072. doi: 10.1371/journal.pone.0125072. eCollection 2015.
Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine.
Capan-Melser M, Mombo Ngoma G, Akerey-Diop D, Basra A, Würbel H, Groger M, Mackanga JR, Zoleko-Manego R, Schipulle U, Schwing J, Lötsch F, Rehman K, Matsiegui PB, Agnandji ST, Adegnika AA, Bélard S, González R, Kremsner PG, Menendez C, Ramharter M.
J Antimicrob Chemother. 2015;70(6):1898-902. doi: 10.1093/jac/dkv041. Epub 2015 Feb 25.
Loa loa Infection in Pregnant Women, Gabon.
Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, Lötsch F, Yazdanbakhsh M, González R, Menendez C, Mabika B, Matsiegui PB, Kremsner PG, Ramharter M.
Emerg Infect Dis. 2015 May;21(5):899a-901. doi: 10.3201/eid2105.141471.
Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria.
Lötsch F, Auer-Hackenberg L, Groger M, Rehman K, Morrison V, Holmes E, Parveen S, Plumpton C, Clyne W, de Geest S, Dobbels F, Vrijens B, Kardas P, Hughes D, Ramharter M.
Wien Klin Wochenschr. 2015 May;127(9-10):379-84. doi: 10.1007/s00508-015-0782-y. Epub 2015 Apr 24.
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.
WWARN Parasite Clearance Study Group, Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D'Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA.
Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.
Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.
Agnandji ST, Fernandes JF, Bache EB, Ramharter M.
Future Microbiol. 2015;10(10):1553-78. doi: 10.2217/fmb.15.90. Epub 2015 Oct 6.
Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.
Belard S, Toepfner N, Capan-Melser M, Mombo-Ngoma G, Zoleko-Manego R, Groger M, Matsiegui PB, Agnandji ST, Adegnika AA, González R, Kremsner PG, Menendez C, Ramharter M, Berner R.
Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease.
Knafl D, Lötsch F, Burgmann H, Goliasch G, Poeppl W, Ramharter M, Thalhammer F, Schuster C
Case Rep Infect Dis. 2015;2015:317260. doi: 10.1155/2015/317260. Epub 2015 Oct 21.
Case report: spontaneous rupture of spleen in patient with Plasmodium ovale malaria.
Lemmerer R, Unger M, Voßen M, Forstner C, Jalili A, Starzengruber P, Werzowa J, Ramharter M, Winkler S, Thalhammer F.
Wien Klin Wochenschr. 2016 Jan;128(1-2):74-7. doi: 10.1007/s00508-015-0888-2. Epub 2015 Nov 5.
Neither Single nor a Combination of Routine Laboratory Parameters can Discriminate between Gram-positive and Gram-negative Bacteremia.
Ratzinger F, Dedeyan M, Rammerstorfer M, Perkmann T, Burgmann H, Makristathis A, Dorffner G, Loetsch F, Blacky A, Ramharter M.
Sci Rep. 2015 Nov 2;5:16008. doi: 10.1038/srep16008.
Population Pharmacokinetics of Pyronaridine in Pediatric Malaria Patients.
Ayyoub A, Methaneethorn J, Ramharter M, Djimde AA, Tekete M, Duparc S, Borghini-Fuhrer I, Shin JS, Fleckenstein L.
Antimicrob Agents Chemother. 2015 Dec 14;60(3):1450-8. doi: 10.1128/AAC.02004-15.
Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana.
Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Oteng-Seifah EE, Bedu-Addo G, Phillips RO, Norman B, Burchard G, Feldt T.
PLoS One. 2015 Nov 24;10(11):e0143388. doi: 10.1371/journal.pone.0143388. eCollection 2015.
Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Eberhardt KA, Sarfo FS, Dompreh A, Kuffour EO, Geldmacher C, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Bedu-Addo G, Phillips RO, Norman B, Burchard GD, Feldt T.
Clin Infect Dis. 2015 Nov 15;61(10):1615-23. doi: 10.1093/cid/civ577. Epub 2015 Jul 20.
Group B Streptococci serotype distribution in pregnant women in Ghana: assessment of potential coverage through future vaccines.
Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y, Rolling T, Dekker D, Adu-Sarkodie Y, Eberhardt KA, May J, Cramer JP.
Trop Med Int Health. 2015 Nov;20(11):1516-1524. doi: 10.1111/tmi.12589.
CCN1 mutation is associated with atrial septal defect.
Perrot A, Schmitt KR, Roth EM, Stiller B, Posch MG, Browne EN, Timmann C, Horstmann RD, Berger F, Özcelik C.
Pediatr Cardiol. 2015 Feb;36(2):295-9. doi: 10.1007/s00246-014-1001-8. Epub 2014 Aug 19.
Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon →
Irrua Specialist Teaching Hospital (ISTH), Nigeria, →
Komfo Anokye Teaching Hospital Kumasi (KATH), Ghana →
Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Ghana →
Medizinische Universität Wien/Medical University of Vienna →
Universitätsklinikum Tübingen/University Hospital Tübingen, Germany →
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